Background Understanding patterns of relapse in patients who respond to antidepressant
treatment can inform strategies for prevention of relapse. We aimed to identify distinct …

Introduction: While the short-term response rates to antidepressant medication and placebo
are well established, very little is known about the short-term course of untreated …

Background Treatment resistant depression (TRD) characterizes a subgroup of 10–30% of
patients with major depressive disorder, and is associated with considerable morbidity and …

Remission of depressive symptoms is the goal of all antidepressant therapy. Rating scales
define remission in clinical trials, but it is unclear how well these definitions predict risk of …

Objective: This study investigated the suitability of the Montgomery-Asberg Depression
Rating Scale (MADRS), with a 24-hour recall period (MADRS-24hr), to assess the rapid …

Objective: Almost two-thirds of patients with major depressive disorder do not achieve
remission with initial treatments. Thus, identifying and providing effective, feasible, and safe …

Background Switching antidepressant medications is recommended when an initial
antidepressant is not effective, when it is unable to be tolerated or when there are significant …

Major depressive disorder is expected to become the second leading cause of disability
worldwide by the year 2020. A large proportion of this disability can be attributed to the large …

Background: Comparative evidence for second-step treatment strategies in severe
depression is scarce. Up-titrating a well tolerated selective serotonin reuptake inhibitor …

Objective To estimate the 12‐week remission rate of patients with depressive disorders and
predictors of this in a naturalistic clinical setting in South Korea. Methods For people with …