An NIR Discrete Metallacycle constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for imaging‐guided cancer Radio‐chemotherapy

Y Ding, Z Tong, L Jin, B Ye, J Zhou, Z Sun… - Advanced …, 2022 - Wiley Online Library
To promote the clinical theranostic performances of platinum‐based anticancer drugs,
imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be …

A near-infrared organoplatinum (II) metallacycle conjugated with heptamethine cyanine for trimodal cancer therapy

B Huang, X Liu, G Yang, J Tian, Z Liu, Y Zhu… - CCS …, 2022 - chinesechemsoc.org
Discrete Pt (II) metallacycles have attracted particular attention for the chemotherapeutic
treatment of cancer. However, a single chemotherapy cannot simultaneously balance …

Rhomboidal Pt (II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Y Sun, F Ding, Z Zhou, C Li, M Pu… - Proceedings of the …, 2019 - National Acad Sciences
Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0–1.7 µm) are in
high demand for precise theranostics that minimize autofluorescence, reduce photon …

A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum (ii) metallacycle for efficient cancer imaging and therapy

F Ding, Z Chen, WY Kim, A Sharma, C Li… - Chemical …, 2019 - pubs.rsc.org
The scarcity of efficient imaging technologies for precise cancer treatment greatly drives the
development of new nanotheranostic based platforms that enable both diagnostic and …

Stable and well-organized near-infrared platinum (II)–Acetylide-Based metallacycles-mediated cancer phototherapy

G Li, X Zhang, W Zhao, W Zhao, F Li… - … applied materials & …, 2020 - ACS Publications
The development of metallacycles with high stability and intense near-infrared (NIR)
absorption is important for biomedical applications. However, very few molecular design …

Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

Y Sun, F Ding, Z Chen, R Zhang, C Li… - Proceedings of the …, 2019 - National Acad Sciences
Discrete Pt (II) metallacycles have potential applications in biomedicine. Herein, we
engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that …

Antitumor activity of a unique polymer that incorporates a fluorescent self-assembled metallacycle

G Yu, M Zhang, ML Saha, Z Mao, J Chen… - Journal of the …, 2017 - ACS Publications
Despite the well-known anticancer activity of mono-and multinuclear platinum complexes,
studies of the antitumor performances of platinum-based supramolecular coordination …

Fluorescent metallacycle-cored polymers via covalent linkage and their use as contrast agents for cell imaging

M Zhang, S Li, X Yan, Z Zhou… - Proceedings of the …, 2016 - National Acad Sciences
The covalent linkage of supramolecular monomers provides a powerful strategy for
constructing dynamic polymeric materials whose properties can be readily tuned either by …

Tetraphenylethene-based highly emissive metallacage as a component of theranostic supramolecular nanoparticles

G Yu, TR Cook, Y Li, X Yan, D Wu… - Proceedings of the …, 2016 - National Acad Sciences
A theranostic agent combines diagnostic reporter with therapeutic activity in a single entity,
an approach that seeks to increase the efficacy of cancer treatment. Herein, we describe the …

pH-responsive, self-sacrificial nanotheranostic agent for potential in vivo and in vitro dual modal MRI/CT imaging, real-time, and in situ monitoring of cancer therapy

L Yue, J Wang, Z Dai, Z Hu, X Chen, Y Qi… - Bioconjugate …, 2017 - ACS Publications
Multifunctional nanotheranostic agents have been highly commended due to the application
to image-guided cancer therapy. Herein, based on the chemically disordered face centered …