SUN-442 EGFR/ErbB2 targeted therapy for aggressive prolactinomas

O Cooper, V Bonert, J Rudnick… - Journal of the …, 2019 - academic.oup.com
Introduction: Prolactinomas are usually benign and respond well to dopamine agonist
therapy. However, approximately 20% are resistant, and 10% behave aggressively and …

[HTML][HTML] Morbid obesity due to prolactinoma and significant weight loss after dopamine agonist treatment

M Ali, L Mirza - AACE Clinical Case Reports, 2021 - Elsevier
Objective Morbid obesity may be related to a prolactinoma, although uncommon, and can
lead to adverse effects like insulin resistance and metabolic syndrome. Recent research …

Clinical, hormonal, and neuroradiological characteristics and therapeutic outcomes of prolactinomas in children and adolescents at a single center

A Yang, SY Cho, H Park, MS Kim, DS Kong… - Frontiers in …, 2020 - frontiersin.org
Background/Purpose: A prolactinoma is the most common pituitary adenoma, but it is
relatively rare in childhood and adolescence. There is only limited research about the …

Pediatric prolactinoma: initial presentation, treatment, and long-term prognosis

A Hoffmann, S Adelmann, K Lohle, A Claviez… - European journal of …, 2018 - Springer
Prolactinoma is a rare pituitary adenoma secreting prolactin. Studies on diagnostics,
treatment, and prognosis in pediatric prolactinoma patients are rare. We analyzed clinical …

Surgery as a viable alternative first-line treatment for prolactinoma patients. A systematic review and meta-analysis

AH Zamanipoor Najafabadi… - The Journal of …, 2020 - academic.oup.com
Context The improved remission and complication rates of current transsphenoidal surgery
warrant reappraisal of the position of surgery as a viable alternative to dopamine agonists in …

Prolactinoma ErbB receptor expression and targeted therapy for aggressive tumors

O Cooper, A Mamelak, S Bannykh, J Carmichael… - Endocrine, 2014 - Springer
As ErbB signaling is a determinant of prolactin synthesis, role of ErbB receptors was tested
for prolactinoma outcomes and therapy. The objective of this study was to characterize ErbB …

Prolactinoma in childhood and adolescence—Tumour size at presentation predicts management strategy: Single centre series and a systematic review and meta …

VB Arya, SJB Aylwin, T Hulse… - Clinical …, 2021 - Wiley Online Library
Objective To report the clinical presentation, management and outcomes of young patients
with prolactinomas (< 20 years) and conduct a systematic review and meta‐analysis …

[PDF][PDF] Update in prolactinomas

M Kars, OM Dekkers, AM Pereira, JA Romijn - Neth J Med, 2010 - njmonline.nl
105 march 2010, vol. 68, no 3 rate similar to that of immunoglobulins. Depending on the
immunoassay used, macro prolactinaemia accounts for up to 25% of biochemically …

Update on prolactinomas. Part 1: Clinical manifestations and diagnostic challenges

A Wong, JA Eloy, WT Couldwell, JK Liu - Journal of clinical neuroscience, 2015 - Elsevier
The authors provide an update on the clinical manifestations and diagnostic challenges of
prolactinomas. Prolactinomas are the most common pituitary adenoma seen in clinical …

Dopamine agonists in prolactinomas: when to withdraw?

P Souteiro, S Belo, D Carvalho - Pituitary, 2020 - Springer
Dopamine agonists (DAs) are well recognized as the first-line therapy for prolactinomas due
to their efficacy in achieving tumoral shrinkage and normoprolactinemia. However, it …