Background The Organ Care System, an ex-vivo heart perfusion platform, represents an
alternative to the current standard of cold organ storage that sustains the donor heart in a …

Ventricular assist devices have become standard therapy for patients with advanced heart
failure either as a bridge to transplantation or destination therapy. Despite the functional and …

The prevalence of heart failure is increasing, and the prognosis of end-stage heart failure
remains dismal. The gold-standard therapy in end-stage heart failure remains cardiac …

A summary of the scientific rationale of the advancements that led to the first genetically
modified pig-to-human cardiac xenotransplantation is lacking in a complex and rapidly …

Heart transplantation remains the treatment of reference for patients experiencing end‐stage
heart failure; unfortunately, graft availability through conventional donation after brain death …

Cardiac transplantation remains the gold standard in the treatment of advanced heart failure.
With advances in immunosuppression, long-term outcomes continue to improve despite …

Although the outcomes of device therapy are still limited by device durability and
complications, the potential of Destination Therapy should continue to expand through the …

Heart transplantation remains the preferred option for improving quality of life and survival
for patients suffering from end-stage heart failure. Unfortunately, insufficient supply of …

Reflecting on the first genetically engineered pig-to-human heart transplantation in this
Clinical Outlook article, we discuss the likely future of cardiac xenotransplantation. Initial …

Cardiac transplantation, first introduced 30 years ago, has become a widely used and
increasingly important procedure for treatment of truly end-stage heart disease. Current use …