Recently, using 2D-DIGE proteomics we have identified cathepsin B as a novel target of
UVA in human Hs27 skin fibroblasts. In response to chronic exposure to noncytotoxic doses …

Cutaneous exposure to chronic solar UVA-radiation is a causative factor in
photocarcinogenesis and photoaging. Recently, we have identified the thiol-dependent …

Solar UVA exposure plays a causative role in skin photoaging and photocarcinogenesis.
Here, we describe the proteomic identification of novel UVA‐targets in human dermal …

Autophagy has been associated with a variety of diseases especially aging. Human dermal
fibroblasts (HDFs) can internalize and then degrade elastin, collagen and advanced …

Luteolin (LUT) is a flavone, which is universally present as a constituent of traditional
Chinese herbs, and certain vegetables and spices, and has been demonstrated to exhibit …

Autophagy is a self-digestive pathway that helps to maintain cellular homeostasis, and many
autophagy-related gene (ATG) s involved the regulation of the autophagy process …

Background: Cathepsin L (CatL) is a cysteine protease with strong matrix degradation
activity that contributes to photoaging. Mannose phosphate-independent sorting pathways …

Senescence is a cellular process that can be initiated by certain stressors such as UVA
irradiation. The mechanism by which skin cells protect themselves from the UVA-induced …

Abstract Background/Purpose Ultraviolet (UV) A (315‐400 nm) is the UV light that most
frequently reaches the Earth's surface and can penetrate the epidermis through to the …

Ultraviolet (UV) irradiation is a major environmental carcinogen involved in the development
of skin cancer. To elucidate the initial signaling during UV-induced damage in human …