Hypoxia inducible factor 1 (HIF-1) is a transcription factor composed of two subunits, namely,
HIF-1α and HIF-1β, in which HIF-1β is constitutively expressed. HIF-1 upregulates several …

Background Pancreatic cancer is a devastating disease that is characterized by persistent
hypoxia. The roles of hypoxia-inducible factor-2α (hif-2α) are different to those of hif-1α …

Background Hypoxia plays a critical role in many cancers. Hypoxia inducible factor-1α (HIF-
1α) is an important mediator of the hypoxia response. It regulates the expression of various …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant carcinoma with an
extremely high lethality. We recently reported that hypoxia-inducible factor 1 (HIF-1) targets …

Stem cell factor (SCF) and hypoxia-inducible factor-1α (HIF-1α) both have important
functions in pancreatic ductal adenocarcinoma (PDAC). This study aims to analyze the …

Background: Intratumoral hypoxia is known to lead to increased aggressiveness and distant
metastasis. However, the interplay underlying these actions is still unknown. Objective: We …

The aim of this study was to assess the significance of expression of hypoxia-inducible factor-
1α (HIF-1α) and associated proteins in pancreatic ductal adenocarcinoma (PDA) and their …

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is
characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha …

Cancer-associated fibroblasts (CAF) are a major cell type in the stroma of solid tumors and
can exert both tumor-promoting and tumor-restraining functions. CAF heterogeneity is …

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal digestive tract
malignancies. Hypoxia-inducible factor (HIF-1) is over-expressed in pancreatic cancer and …