Risk assessment of the inhibition of hydroxygenkwanin on human and rat cytochrome P450 by cocktail method

J Gao, Y Zhang, X Lei, Y Xu, Z Sun, X Wang - Toxicology in Vitro, 2022 - Elsevier
Hydroxygenkwanin (HGK), a natural flavonoid extracted from the buds of Daphne genkwa
Sieb. et Zucc.(Thymelaeaceae), possesses a wide range of pharmacological activities …

Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay

S Tang, A Chen, X Zhou, L Zeng, M Liu, X Wang - Toxicology Letters, 2017 - Elsevier
Shikonin is a naphthoquinone pigment extracted from roots of Lithospermum erythrorhizon
Sieb. et Zucc.(Boraginaceae), and possesses various pharmaceutical activities, such as anti …

Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc

Y Zhang, J Gao, Y Xu, J Liu, S Huang, G Li… - Phytotherapy …, 2022 - Wiley Online Library
Deoxyshikonin, a natural naphthoquinone compound extracted from Lithospermum
erythrorhizon Sieb. et Z ucc (Boraginaceae), has a wide range of pharmacological activities …

Acetylshikonin is a novel non‐selective cytochrome P450 inhibitor

JC Shon, NM Phuc, WC Kim, JK Heo… - … & Drug Disposition, 2017 - Wiley Online Library
Acetylshikonin is a biologically active compound with anti‐cancer and anti‐inflammatory
activity, which is isolated from the roots of Lithospermum erythrorhizoma. An inhibitory effect …

[HTML][HTML] The time-dependent effects of St John's wort on cytochrome P450, uridine diphosphate-glucuronosyltransferase, glutathione S-transferase, and NAD (P) H …

JF Yang, YR Liu, CC Huang, YF Ueng - journal of food and drug analysis, 2018 - Elsevier
Abstract Hypericum perforatum [St. John's wort (SJW)] is known to cause a drug interaction
with the substrates of cytochrome P450 (P450, CYP) isoforms, mainly CYP3A. This study …

In vitro inhibition and induction of human liver cytochrome P450 enzymes by gentiopicroside: potent effect on CYP2A6

Y Deng, L Wang, Y Yang, W Sun, R Xie, X Liu… - Drug Metabolism and …, 2013 - Elsevier
Gentiopicroside (GE), a naturally occurring iridoid glycoside, has been developed into a
Novel Traditional Chinese Drug named gentiopicroside injection, and it was approved for …

[PDF][PDF] Effects of Kaempferia galanga L. and ethyl-p-methoxycinnamate (EPMC) on hepatic microsomal cytochrome P450s enzyme activities in mice.

W Sirisangtragul, B Sripanidkulchai - Songklanakarin Journal of …, 2011 - thaiscience.info
Kaempferia galanga L.(K. galanga L.), belonging to the Zingiberaceae family, has been
widely used in Thai traditional medicine for treatment of hypertension, asthma, rheumatism …

Evaluation of the inhibitory effect of Gynostemma pentaphyllum extracts on CYP450 enzyme activities using LC-MS/MS

JS Yu, YS Ji, SY Jo, XL Piao… - Mass Spectrometry …, 2023 - repository.hanyang.ac.kr
Gynostemma pentaphyllum (Thunb.) Makino extract, a natural product with a history of
traditional use, has gained attention for its potential health benefits. This study aimed to …

Modulation of CYP3A4 and CYP2C9 activity by Bulbine natalensis and its constituents: An assessment of HDI risk of B. natalensis containing supplements

I Husain, V Manda, M Alhusban, OR Dale, JY Bae… - Phytomedicine, 2021 - Elsevier
Background Bulbine natalensis is an African-folk medicinal plant used as a dietary
supplement for enhancing sexual function and muscle strength in males by presumably …

In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes

N Zhang, J Liu, Z Chen, W Dou - Pharmaceutical biology, 2019 - Taylor & Francis
Context: Kaempferitrinis (KF) is a bioactive flavonoid and possesses numerous
pharmacological activities. However, whether KF affects the activity of human liver …