Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …

Pancreatic islets are clusters of endocrine cells that secrete different hormones to regulate
blood glucose levels. Efficient hormone secretion requires a close interaction of endocrine …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …

Human and rodent islets differ substantially in several features, including architecture, cell
composition, gene expression and some aspects of insulin secretion. Mouse pancreatic …

The extracellular matrix (ECM) critically affects β cell functions via integrin activation. But
whether these ECM actions drive the spatial organization of β cells, as they do in epithelial …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

It is generally accepted that vascularization and oxygenation of pancreatic islets are
essential for the maintenance of an optimal β-cell mass and function and that signaling by …

The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …