Acute myeloid leukemia (AML) is a hematological malignancy with an alarming mortality
rate. The development of novel therapeutic targets or drugs for AML is urgently needed …

Osteosarcoma (OS) is the most frequent primary malignant bone tumor. Ferroptosis, a form
of regulated cell death, is a key tumor suppression mechanism. Although methionine …

Studies have indicated dietary restriction of methionine/cystine provided a therapeutic
benefit in diseases such as cancer. However, the molecular and cellular mechanisms that …

The incidence of melanoma is increasing over the years with a still poor prognosis and the
lack of a cure able to guarantee an adequate survival of patients. Although the new immuno …

Background. Ferroptosis and autophagy have an important role in the occurrence and
development of cancer, and lactate in cells and microenvironment is one of the influencing …

Ferroptosis has demonstrated significant potential in treating radiochemotherapy-resistant
cancers, but its efficacy can be affected by recently discovered ferroptosis suppressors. In …

Background Ovarian cancer (OV) is a gynecologic tumor with high mortality due to its drug
resistance. In most cases, simple standard care is not satisfactory. Ferroptosis as a non …

Aims Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance.
Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin …

Ferroptosis, a type of regulated cell death brought about by lipid peroxidation, has been
discovered to suppress tumor growth. Here, we report that targeting RRM1 promotes …

mTOR exists in two distinct complexes. mTOR complex 1 (mTORC1) is potently inhibited by
the immunosupressive macrolide rapamycin; whereas, mTORC2 is insensitive to this drug …