Our current understanding of protective measures for avoiding ventilator-induced lung injury
(VILI) has evolved from targeting low tidal volumes to lowering plateau and driving pressure …

Ventilation is inherently a dynamic process. The present-day clinical practice of
concentrating on the static inflation characteristics of the individual tidal cycle (plateau …

It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not
been reduced in over 15 years and remains~ 40%, even with protective low tidal volume …

At the bedside, assessing the risk of ventilator-induced lung injury (VILI) requires parameters
readily measured by the clinician. For this purpose, driving pressure (DP) and end …

Mechanical ventilation is a life-saving therapy in several clinical situations, promoting gas
exchange and providing rest to the respiratory muscles. However, mechanical ventilation …

As currently implemented, lung protective ventilation concentrates on certain static
characteristics of the individual tidal cycle—tidal volume (TV), plateau pressure, PEEP, and …

The pathophysiological mechanisms by which mechanical ventilation can contribute to lung
injury, termed “ventilator-induced lung injury”(VILI), is increasingly well understood.“ …

Despite over 40 years of research, there is no specific lung-directed therapy for the acute
respiratory distress syndrome (ARDS). Although much has evolved in our understanding of …

Repeated applications of tidal energy inflict lung damage (VILI) when stress and strain
exceed the limits of tissue tolerance. Inflation work and energy are the products of pressure …

Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …