The liver plays a central role in the biotransformation of a variety of drugs and xenobiotics.
During the biotransformation of drugs and chemicals, the liver generates various reactive …

This chapter describes the implication of oxidative stress in the progression of the liver
diseases with higher prevalence worldwide: nonalcoholic fatty liver disease, cholestasis …

Oxidative stress and liver injury are strongly associated. Oxidative stress in the liver can be
triggered during different conditions and by specific etiologies, including hepatotoxins …

The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

Oxidative stress and inflammation are hallmarks of virtually all (chronic) liver diseases. Not
surprisingly, understanding the role of oxidative stress and its deleterious consequences …

Oxidative stress has recently been shown to play an important role in various liver diseases.
Therefore, further studies on oxidative stress in liver diseases are urgently required. In this …

THE IMPORTANCE OF REACTIVE OXYGEN SPECIES is well recognized in a number of
liver diseases, including inflammatory conditions. However, the molecular mechanisms have …

A complex antioxidant system has been developed in mammals to relieve oxidative stress.
However, excessive reactive species derived from oxygen and nitrogen may still lead to …

Liver diseases are a worldwide medical problem because the liver is the principal
detoxifying organ and maintains metabolic homeostasis. The liver metabolizes various …

In humans, oxidative stress and antioxidant defenses are the sum of a complicated network
of enzymatic and non‐enzymatic processes. Depending on the stage and severity of …