Proxy phenotypes allow for the utilization of genetic data from large population cohorts to
analyze late-onset diseases by using parental diagnoses as a proxy for genetic disease risk …

Proxy phenotypes allow for the utilization of genetic data from large population cohorts to
analyze late-onset diseases by using parental diagnoses as a proxy for genetic disease risk …

Alzheimer's disease (AD) is the most common form of late-onset neurodegenerative
disease. Previous genome-wide association studies have identified numerous common …

Alzheimer's Disease (AD) is a common disorder of the elderly that is both highly heritable
and genetically heterogeneous. Here, we investigated the association between AD and both …

Introduction Analysis of sequence data in high‐risk pedigrees is a powerful approach to
detect rare predisposition variants. Methods Rare, shared candidate predisposition variants …

Alzheimer's disease (AD) is a prevalent and hugely impactful disease affecting millions.
Despite the large public health impact, only two pharmacological treatments have been …

Background Alzheimer disease (AD) is a neurodegenerative disease with a common late-
onset (LOAD) subtype and a less frequent, typically familial early-onset (EOAD) subtype …

Analyses of genome-wide association studies (GWAS) for complex disorders usually identify
common variants with a relatively small effect size that only explain a small proportion of …

Importance Some of the unexplained heritability of Alzheimer disease (AD) may be due to
rare variants whose effects are not captured in genome-wide association studies because …

Background The largest Alzheimer disease (AD) Genome-wide Association Studies (GWAS)
to date, conducted by the International Genomics of Alzheimer's Project (IGAP) in 2013 …