DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell …
J Kasparkova, V Marini, Y Najajreh, D Gibson… - Biochemistry, 2003 - ACS Publications
The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis-
or trans-[PtCl2 (NH3)(Am)], where Am= NH3, nonplanar heterocycle piperidine, piperazine …
or trans-[PtCl2 (NH3)(Am)], where Am= NH3, nonplanar heterocycle piperidine, piperazine …
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand
R Prokop, J Kasparkova, O Novakova, V Marini… - Biochemical …, 2004 - Elsevier
The global modification of mammalian and plasmid DNAs by novel platinum compounds,
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand: Mechanistic studies on antitumor action
J Kasparkova, O Novakova, V Marini, Y Najajreh… - Journal of Biological …, 2003 - ASBMB
A paradigm for the structure-pharmacological activity relationship of bifunctional platinum
antitumor drugs is that the trans isomer of antitumor cisplatin (transplatin) is clinically …
antitumor drugs is that the trans isomer of antitumor cisplatin (transplatin) is clinically …
DNA Binding by Antitumor trans-[PtCl2(NH3)(thiazole)]. Protein Recognition and Nucleotide Excision Repair of Monofunctional Adducts
J Kasparkova, O Novakova, N Farrell, V Brabec - Biochemistry, 2003 - ACS Publications
Antitumor effects of cis-diamminedichloroplatinum (II)(cisplatin) and the clinical inactivity of
its trans isomer (transplatin) have been considered a paradigm for the classical structure …
its trans isomer (transplatin) have been considered a paradigm for the classical structure …
DNA Adducts of Antitumor Trans -[PtCl 2 ( E -Imino Ether) 2 ]
V Brabec, O Vrána, O Nováková… - Nucleic acids …, 1996 - academic.oup.com
It has been shown recently that some analogues of clinically ineffective trans-
diamminedichloroplatinum (II)(transplatin) exhibit antitumor activity. This finding has inverted …
diamminedichloroplatinum (II)(transplatin) exhibit antitumor activity. This finding has inverted …
Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands
S Zorbas-Seifried, MA Jakupec, NV Kukushkin… - Molecular …, 2007 - ASPET
The presence of cis-configured exchangeable ligands has long been considered a
prerequisite for antitumor activity of platinum complexes, but over the past few years, several …
prerequisite for antitumor activity of platinum complexes, but over the past few years, several …
DNA interactions of antitumor trans‐[PtCl2(NH3)(quinoline)]
A Žákovská, O Nováková, Z Balcarová… - European journal of …, 1998 - Wiley Online Library
Recent observations that several trans‐platinum complexes exhibit antitumor activity
including activity in cisplatin‐resistant tumor cells, violates the classical structure/activity …
including activity in cisplatin‐resistant tumor cells, violates the classical structure/activity …
Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand
Y Najajreh, J Kasparkova, V Marini, D Gibson… - JBIC Journal of …, 2005 - Springer
Abstract trans-Diaminedicholoroplatinum (II) complexes with one planar and one non-planar
heterocyclic amine ligand were designed as new potential antitumor drugs. The X-ray …
heterocyclic amine ligand were designed as new potential antitumor drugs. The X-ray …
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups
V Brabec, K Neplechova, J Kasparkova… - Journal of Biological …, 2000 - Springer
Recent findings that novel trans-dichloroplatinum (II) complexes exhibit antitumor activity
violate the classical structure-activity relationships of platinum (II) complexes. These novel …
violate the classical structure-activity relationships of platinum (II) complexes. These novel …
Activation of the trans Geometry in Platinum Antitumor Complexes: A Survey of the Cytotoxicity of trans Complexes Containing Planar Ligands in Murine L1210 and …
N Farrell, LR Kelland, JD Roberts, M Van Beusichem - Cancer Research, 1992 - AACR
The cytotoxicity of transplatinum complexes of structural formula trans-[PtCl2 (L)(L′)][L=
L′= pyridine or thiazole, or L= quinoline (R′= methyl; R ″= methyl, phenyl, or CH2phenyl) …
L′= pyridine or thiazole, or L= quinoline (R′= methyl; R ″= methyl, phenyl, or CH2phenyl) …
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