Structural overview of the bacterial injectisome

LJ Worrall, E Lameignere, NCJ Strynadka - Current opinion in microbiology, 2011 - Elsevier
The bacterial injectisome is a specialized protein-export system utilized by many pathogenic
Gram-negative bacteria for the delivery of virulence proteins into the hosts they infect. This …

[HTML][HTML] Recent structural advances towards understanding of the bacterial type III secretion injectisome

J Jenkins, LJ Worrall, NCJ Strynadka - Trends in Biochemical Sciences, 2022 - cell.com
The bacterial injectisome is a structurally conserved, syringe-shaped nanomachine that
spans the Gram-negative envelope and forms a continuous channel for type III secretion of …

Piecing together the type III injectisome of bacterial pathogens

TF Moraes, T Spreter, NCJ Strynadka - Current opinion in structural biology, 2008 - Elsevier
The Type III secretion system is a bacterial 'injectisome'which allows Gram-negative bacteria
to shuttle virulence proteins directly into the host cells they infect. This macromolecular …

The type III secretion injectisome

GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …

T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly

J Hu, LJ Worrall, M Vuckovic, C Hong, W Deng… - Nature …, 2019 - nature.com
The bacterial injectisome is a syringe-shaped macromolecular nanomachine utilized by
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …

Investigating the assembly of the bacterial type III secretion system injectisome by in vivo photocrosslinking

N Singh, S Wagner - International Journal of Medical Microbiology, 2019 - Elsevier
Virulence-associated type III secretion systems serve the injection of bacterial effector
proteins into eukaryotic host cells. These effector proteins modulate host cell biology in order …

The injectisome, a complex nanomachine for protein injection into mammalian cells

M Lara-Tejero, JE Galán - EcoSal Plus, 2019 - Am Soc Microbiol
Type III protein secretion systems (T3SSs), or injectisomes, are multiprotein nanomachines
present in many Gram-negative bacteria that have a sustained long-standing close …

Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome

EZ Guo, JE Galán - … of the National Academy of Sciences, 2021 - National Acad Sciences
Type III secretion systems are multiprotein molecular machines required for the virulence of
several important bacterial pathogens. The central element of these machines is the …

Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

J Hu, LJ Worrall, C Hong, M Vuckovic… - Nature …, 2018 - nature.com
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …

Common and distinct structural features of Salmonella injectisome and flagellar basal body

A Kawamoto, YV Morimoto, T Miyata, T Minamino… - Scientific reports, 2013 - nature.com
Bacterial pathogens use an injectisome to deliver virulence proteins into eukaryotic host
cells. The bacterial flagellum and injectisome export their component proteins for self …