Alpha-1-antitrypsin (A1AT) deficiency is an autosomal hereditary disorder associated with a
major reduction in serum A1AT levels. Clinically, A1AT deficiency is associated with …

Background: Laboratory testing in suspected α-1-antitrypsin (A1AT) deficiency involves
analysis of A1AT concentrations and identification of specific alleles by genotyping or …

Summary Alpha‐1 antitrypsin (A1AT) is a serine anti‐protease produced chiefly by the liver.
A1AT deficiency is a genetic disorder characterized by serum levels of less than 11 μmol/L …

Alpha1-Antitrypsin Deficiency AAT is a protease inhibitor targeting neutrophil elastase. It
prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT …

The S-type α1-antitrypsin (α1AT) deficiency allele differs from the normal M1 (Val 213) allele
by a single amino acid substitution (Glu 264→ Val). To evaluate the molecular …

The major physiological role of the serine protease inhibitor alpha 1-antitrypsin (alpha 1-AT)
is to protect elastic fibers in the lung from excessive hydrolysis by neutrophil elastase …

Extremely deficient levels of α-1-antitrypsin (α1AT) predispose such deficientindividuals to
the development of emphysema and cirrhosis. Protease inhibitor (Pi) typing has clarified that …

Abstract Alpha‐1 antitrypsin (AAT) deficiency is an under‐recognized hereditary disorder
associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis …

Hepatocytes are considered to be the predominant source of alpha 1-antitrypsin (AAT), the
major antiprotease in human plasma. The development of emphysema in the hereditary PiZ …

Abstract Alpha-1-antitrypsin (α 1 AT) is one of several protease inhibitors in serum which
together control proteases involved in such vital processes as activation of the clotting …