The developmental process of neurulation involves a series of coordinated morphological
events, which result in conversion of the flat neural plate into the neural tube, the primordium …

Neurulation is a morphogenetic event par excellence. During this highly choreographed four-
dimensional process, a flat sheet of ectoderm is transformed into an elongated tubular …

Cranial neurulation is the embryonic process responsible for formation of the brain
primordium. In the mouse embryo, cranial neurulation is a piecemeal process with several …

Neurulation, the process of neural tube formation, is a complex morphogenetic event. In the
mammalian embryo, an understanding of the dynamic nature of neurulation has been …

The central nervous system of vertebrate embryos originates from the neural tube (NT), a
simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of …

In higher vertebrates, the primordium of the nervous system, the neural tube, is shaped
along the rostrocaudal axis through two consecutive, radically different processes referred to …

The neural groove and folds are first seen during stage 8 (about 18 postovulatory days). Two
days later (stage 9) the three main divisions of the brain, which are not cerebral vesicles, can …

We review the data from studies of mouse mutants that lend insight to the mechanisms that
lead to neural tube defects (NTDs). Most of the 50 single‐gene mutations that cause neural …

The vertebrate neural tube develops by two distinct mechanisms. Anteriorly, in the brain and
future trunk (cervicothoracic) region,'primary neurulation'occurs, where an epithelial sheet …

Neurulation occurs during the early embryogenesis of chordates, and it results in the
formation of the neural tube, a dorsal hollow nerve cord that constitutes the rudiment of the …