Radiotherapy combined with immunotherapy: the dawn of cancer treatment

Z Zhang, X Liu, D Chen, J Yu - Signal Transduction and Targeted …, 2022 - nature.com
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …

Radiation effects on antitumor immune responses: current perspectives and challenges

T Walle, R Martinez Monge… - … in medical oncology, 2018 - journals.sagepub.com
Radiotherapy (RT) is currently used in more than 50% of cancer patients during the course
of their disease in the curative, adjuvant or palliative setting. RT achieves good local control …

Mechanisms and therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy

WD Yu, G Sun, J Li, J Xu, X Wang - Cancer letters, 2019 - Elsevier
Immunotherapies based on T cells have gained significant success in the treatment of
diverse cancers, however, several limitations also exist, including low response, acquired …

Using immunotherapy to boost the abscopal effect

W Ngwa, OC Irabor, JD Schoenfeld, J Hesser… - Nature Reviews …, 2018 - nature.com
More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression
of metastatic cancer at distant sites that are not irradiated was described and called the …

The immune mechanisms of abscopal effect in radiation therapy

GD Grass, N Krishna, S Kim - Current problems in cancer, 2016 - Elsevier
Radiation therapy (RT) is a cornerstone in oncologic management and is employed in
various curative and palliative scenarios for local-regional control. RT is thought to locally …

The abscopal effect: a review of pre-clinical and clinical advances

JR Janopaul-Naylor, Y Shen, DC Qian… - International journal of …, 2021 - mdpi.com
Radiotherapy has been used for more than a hundred years to cure or locally control tumors.
Regression of tumors outside of the irradiated field was occasionally observed and is known …

The synergistic effect of radiotherapy and immunotherapy: A promising but not simple partnership

E Chajon, J Castelli, H Marsiglia… - Critical reviews in …, 2017 - Elsevier
Radiotherapy (RT) is one of the main components in the treatment of cancer. The better
understanding of the immune mechanisms associated with tumor establishment and how RT …

Abscopal effect in radioimmunotherapy

M Ashrafizadeh, B Farhood, AE Musa, S Taeb… - International …, 2020 - Elsevier
Abscopal effect is an interesting phenomenon in radiobiology that causes activation of
immune system against cancer cells. Traditionally, this phenomenon was known as a …

Radiotherapy and the immune system: More than just immune suppression

M Rückert, AS Flohr, M Hecht, US Gaipl - Stem Cells, 2021 - academic.oup.com
Radiotherapy (RT) is still one of the standard cancer therapies, with up to two third of all
cancer patients with solid tumors being irradiated in the course of their disease. The aim of …

Modern radiotherapy concepts and the impact of radiation on immune activation

L Deloch, A Derer, J Hartmann, B Frey, R Fietkau… - Frontiers in …, 2016 - frontiersin.org
Even though there is extensive research carried out in radiation oncology, most of the
clinical studies focus on the effects of radiation on the local tumor tissue and deal with …