This study was designed to demonstrate that dopaminergic stimulation would result in
decreased smoking behavior and nicotine intake, whereas dopaminergic blockade would …

Rationale: Studies with laboratory animals and humans suggest that dopamine may play a
role in maintaining cigarette smoking behavior via its interactions with nicotine. Objectives …

Researchers have hypothesized that dopamine mediates the reinforcing effects of stimulant
drugs, including nicotine. Three experiments tested whether manipulating dopamine would …

The mesolimbic dopaminergic system appears to mediate the rewarding effects of certain
stimulant drugs, such as (+) amphetamine. Autoradiographic mapping techniques have …

Both preclinical and clinical evidence suggest that brain dopamine (DA) systems are
involved in conditioned responses to drug cues. In smokers, such responses to smoking …

Aims. Animal studies have shown that nicotine releases dopamine, a neurotransmitter
implicated in drug reinforcement. We hypothesized that bromocriptine would decrease …

Craving is thought to play an important role in maintaining regular smoking patterns in
current smokers, and in leading to relapse in smokers attempting to quit. Within the scientific …

Overnight smoking abstinence increases desire to smoke and intensity of smoking behavior
in smokers, but it is not completely clear that this reflects an increase in reinforcement from …

The effects of the acute administration of nicotine [through nicotine inhalers (NI) and placebo
inhalers (PI)], nicotine-containing tobacco (NT), and denicotinized tobacco (DT), on smokers' …

An aspect of nicotine reinforcement that may contribute to tobacco addiction is the effect of
nicotine to enhance the motivational properties of reward-associated cues, or conditioned …