Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure

L Golden-Mason, L Madrigal-Estebas, E McGrath… - Gut, 2008 - gut.bmj.com
Background: Natural killer (NK) cells may be impaired in patients with persistent hepatitis C
virus (HCV) infection, but studies to date have yielded inconsistent findings due to patient …

Reduced frequencies of NKp30+ NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance

G Alter, S Jost, S Rihn, LL Reyor, BE Nolan… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: While the majority of HCV-infected patients progress to chronic
hepatitis, a small fraction of individuals are able to clear the virus. Resolution of infection …

[PDF][PDF] Natural killer cell function is intact after direct exposure to infectious hepatitis C virions

JC Yoon, M Shiina, G Ahlenstiel, B Rehermann - Hepatology, 2009 - Wiley Online Library
Although hepatitis C virus (HCV) has been shown to readily escape from virus‐specific T
and B cell responses, its effects on natural killer (NK) cells are less clear. Based on two …

Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C

P Bonorino, M Ramzan, X Camous… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: The fate of intrahepatic NK cell subsets in the course of HCV and
HBV infections is not clearly understood. METHODS: Blood and intrahepatic CD56+ NK cell …

Compromised function of natural killer cells in acute and chronic viral hepatitis

S Lunemann, DFG Malone, J Hengst… - The Journal of …, 2014 - academic.oup.com
Background. Natural killer (NK) cells are an integral part of the innate immune system. They
have been suggested to play an important role in both defense against viral hepatitis and …

Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C

J Nattermann, G Feldmann, G Ahlenstiel, B Langhans… - Gut, 2006 - gut.bmj.com
Introduction: Impaired activity of natural killer (NK) cells has been proposed as a mechanism
contributing to viral persistence in hepatitis C virus (HCV) infection. As the function of NK …

Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis

A Ahmad, F Alvarez - Journal of leukocyte biology, 2004 - academic.oup.com
Natural killer (NK) cells constitute the first line of host defense against invading pathogens.
They usually become activated in an early phase of a viral infection. Liver is particularly …

Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection

S Crotta, M Brazzoli, D Piccioli, NM Valiante… - Journal of hepatology, 2010 - Elsevier
BACKGROUND & AIMS: Hepatitis C virus (HCV) is remarkably successful in establishing
persistent infections due to its ability to evade host immune responses through a …

Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment

O Dessouki, Y Kamiya, H Nagahama, M Tanaka… - Biochemical and …, 2010 - Elsevier
Impaired activity of NK (natural killer) cells has been proposed as a mechanism contributing
to viral persistence and chronic infection in hepatitis C (HCV) infection. We aimed to assess …

Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa–dependent manner

G Ahlenstiel, RH Titerence, C Koh, B Edlich, JJ Feld… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infection display great
variability in disease activity and progression. Although virus-specific adaptive immune …