[HTML][HTML] Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy

C Sun, H Sun, W Xiao, C Zhang, Z Tian - Acta Pharmacologica Sinica, 2015 - nature.com
The mechanisms linking hepatitis B virus (HBV) and hepatitis C virus (HCV) infection to
hepatocellular carcinoma (HCC) remain largely unknown. Natural killer (NK) cells account …

[HTML][HTML] The role of natural killer cells in liver inflammation

AJ Highton, IS Schuster, MA Degli-Esposti… - Seminars in …, 2021 - Springer
The liver is an important immunological site that can promote immune tolerance or
activation. Natural killer (NK) cells are a major immune subset within the liver, and therefore …

[HTML][HTML] Identification of a distinct NK-like hepatic T-cell population activated by NKG2C in a TCR-independent manner

JY Koh, MS Rha, SJ Choi, HS Lee, JW Han, H Nam… - Journal of …, 2022 - Elsevier
Background & Aims The liver provides a unique niche of lymphocytes enriched with a large
proportion of innate-like T cells. However, the heterogeneity and functional characteristics of …

Natural killer cells in liver disease and hepatocellular carcinoma and the NK cell‐based immunotherapy

P Liu, L Chen, H Zhang - Journal of Immunology Research, 2018 - Wiley Online Library
Nature killer (NK) cells play a critical role in host innate and adaptive immune defense
against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with …

Activation and function of hepatic NK cells in hepatitis B infection: an underinvestigated innate immune response

Y Chen, H Wei, B Gao, Z Hu, S Zheng… - Journal of viral …, 2005 - Wiley Online Library
Natural killer (NK) cells are abundant in the normal liver, accounting for around one‐third of
intrahepatic lymphocytes and are important in the defence against hepatitis B virus (HBV) …

Hepatitis C virus–infected cells downregulate NKp30 and inhibit ex vivo NK cell functions

KA Holder, SN Stapleton, ME Gallant… - The Journal of …, 2013 - journals.aai.org
Hepatitis C virus (HCV) successfully evades the immune system and establishes chronic
infection in∼ 80% of cases. Immune evasion may involve modulating NK cell functions …

Hepatitis C virus infection downregulates the ligands of the activating receptor NKG2D

C Wen, X He, H Ma, N Hou, C Wei, T Song… - Cellular & molecular …, 2008 - nature.com
Natural killer (NK) cells are a major component of the host innate immune defense against
various pathogens. Several viruses, including hepatitis C virus (HCV), have developed …

[PDF][PDF] Natural killer inhibitory receptor expression associated with treatment failure and interleukin‐28B genotype in patients with chronic hepatitis C

L Golden‐Mason, KM Bambha, L Cheng… - …, 2011 - Wiley Online Library
Natural killer (NK) cells constitute a first line of defense against viral infections; their function
is governed by the integration of signals from multiple activating and inhibitory surface …

Profiles of NK, NKT cell activation and cytokine production following vaccination against hepatitis B

B Albarran, L Goncalves, S Salmen, L Borges, H Fields… - Apmis, 2005 - Wiley Online Library
Human natural killer (NK) cells (CD56+ CD3−) represent crucial components of the innate
immune system especially against viral infections and because their activation can modulate …

CMV drives clonal expansion of NKG2C+ NK cells expressing self‐specific KIRs in chronic hepatitis patients

V Béziat, O Dalgard, T Asselah, P Halfon… - European journal of …, 2012 - Wiley Online Library
Natural killer (NK) cells are affected by infection with human cytomegalovirus (HCMV)
manifested by increased expression of the HLA‐E binding activating receptor NKG2C. We …