Conjugation of the 9-kDa isoform of granulysin with liposomes potentiates its cytotoxicity
R Soler-Agesta, P Guerrero-Ochoa… - International Journal of …, 2022 - mdpi.com
Nine kDa granulysin (GRNLY) is a human cytolytic protein secreted by cytotoxic T
lymphocytes (CTL) and NK cells of the immune system whose demonstrated physiological …
lymphocytes (CTL) and NK cells of the immune system whose demonstrated physiological …
[引用][C] Granulysin Induces Cathepsin B Release
Z Fan, H Zhang, C Zhong, L Shi, Y Guo - J Immunol, 2009
Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors
A Aporta, E Catalán, P Galán-Malo… - Biochemical …, 2014 - Elsevier
Granulysin is a protein present in the granules of human CTL and NK cells, with cytolytic
activity against microbes and tumors. Previous work demonstrated that granulysin caused …
activity against microbes and tumors. Previous work demonstrated that granulysin caused …
Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of bid leading to Necroptosis
H Zhang, C Zhong, L Shi, Y Guo… - The Journal of Immunology, 2009 - journals.aai.org
Granulysin is a killer effector molecule localized in cytolytic granules of human NK and CTL
cells. Granulysin exhibits broad antimicrobial activity and potent cytotoxic action against …
cells. Granulysin exhibits broad antimicrobial activity and potent cytotoxic action against …
Granulysin-induced lysis of membranes depends on pH and the net charge of phospholipids
A Kaspar, DA Hanson, AM Krensky, S Hawgood… - Pediatric …, 1999 - nature.com
Granulysin is a newly described peptide expressed by cytotoxic T lymphocytes (CTL) and
Natural Killer (NK) cells which co-localizes with perforin in secretory lytic granules …
Natural Killer (NK) cells which co-localizes with perforin in secretory lytic granules …
Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition
D Sikriwal, P Ghosh, JK Batra - The International Journal of Biochemistry & …, 2008 - Elsevier
Ribosome inactivating proteins (RIPs) are toxic translation inhibitors that kill eukaryotic cells
by arresting protein synthesis at the translocation step. Saporin-6, expressed in the seeds of …
by arresting protein synthesis at the translocation step. Saporin-6, expressed in the seeds of …
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
D Martinvalet, P Zhu, J Lieberman - Immunity, 2005 - cell.com
Granzyme A (GzmA) triggers cell death with apoptotic features by targeting the endoplasmic
reticulum-associated SET complex, which contains the GzmA-activated DNase NM23-H1, its …
reticulum-associated SET complex, which contains the GzmA-activated DNase NM23-H1, its …