Granulysin is a protein present in the granules of human CTL and NK cells, with cytolytic
activity against microbes and tumors. Previous work demonstrated that granulysin induced …

Granulysin (GNLY) is a cytolytic and proinflammatory protein expressed in activated human
cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Conventional mouse models …

The plant toxin saporin is a ribosome‐inactivating protein which inhibits protein synthesis
and growth of both normal and tumour cells. Its cytotoxic activity can be increased by …

Aim To construct an eukaryotic expression vector pBudCE4. 1/GLS encoding human
granulysin (GLS) derived from activated CTLs and observe its effects on cell damage and …

Within the powerful legacy left by Jurg Tschopp, we should not forget his early work that
helped to elucidate the molecular pathways responsible for the clearance of virus-infected …

Granulysin is a cytotoxic granule expressed in cytotoxic T cells and natural killer cells.
Although its cytotoxic effect against a number of tumor cell lines has been demonstrated in …

The ability of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to kill susceptible
targets has been known for over 20 years. This observation led to an intensive if not …

Cytotoxic cell granule-mediated apoptosis is a unique form of cell signaling that entails the
intracellular delivery of granuleassociated serine proteases (granzymes). Recent work has …

The molecular details of cytotoxic granule-mediated apoptosis have been gleaned from the
study of the effects of isolated granzymes and perforin on target cells. Recent evidence …

kDa granulysin is a protein expressed into the granules of human cytotoxic T lymphocytes
(CTL) and natural killer (NK) cells. It has been shown to exert cytolysis on microbes and …