Objective PANoptosis, a new form of regulated cell death, concomitantly manifests hallmarks
for pyroptosis, apoptosis, and necroptosis. It has been usually observed in macrophages, a …

Granzyme (gzm) A and gzmB have been implicated in Fas-independent nucleolytic and
cytolytic processes exerted by cytotoxic T (Tc) cells, but the underlying mechanism (s) …

Granzyme A (GzmA) is considered a major proapoptotic protease. We have discovered that
GzmA-induced cell death involves rapid membrane damage that depends on the synergy …

Spongistatin 1 is a new experimental chemotherapeutic agent isolated from marine
sponges. Here we show that spongistatin 1 potently induces cell death in patient primary …

ゲルソリンによるアポトーシス抑制のメカニズム: ミトコンドリア内膜電位低下およびチトクロム c
放出の阻止

Cell death is mediated by cytotoxic lymphocytes through various granule serine proteases
released with perforin. The unique protease activity, restricted expression, and distinct gene …

Highlights•Granulysin is an antimicrobial peptide in CTL and NK cytotoxic
granules.•Granulysin permeabilizes cholestrerol-poor microbial membranes to deliver …

During the progression of necroptosis and pyroptosis, the plasma membrane will become
permeabilized through the activation of mixed lineage kinase domain like pseudokinase …

Sažetak Introduction: GNLY is a member of the family of saposin-like lipid binding proteins
with pro-apoptotic features that is expressed in activated T, NK, and NKT cells. The function …

Granulysin (GNLY) is a cationic antimicrobial, proinflammatory, and cytotoxic effector protein
primarily expressed in human cytotoxic T and NK cells. Its two variants, the 15 kDa precursor …