We have recently shown that the physiological mediator of granule-mediated apoptosis is a
macromolecular complex of granzymes and perforin complexed with the chondroitin-sulfate …

Cytotoxic T lymphocyte and natural killer cell-initiated cell death is one of the primary
mechanisms used by higher organisms to eliminate viruses and transformed cells. In this …

Caspase-mediated proteolysis is a critical and central element of the apoptotic process;
therefore, it is important to identify the downstream molecular targets of caspases. We …

The neutrophil granulocyte is a key factor in cellular innate defence mechanisms against
infection or tissue damage. Granulocyte apoptosis is now acknowledged to have a critical …

Small molecules which activate distinct cell death pathways have promising high potential
for anticancer drug research. Especially, regulated necrosis draws attention as an …

Cytotoxic lymphocytes (CL) induce death of their targets by granule exocytosis. During this
process, enzymes contained within cytotoxic granules (granzymes) are delivered to the …

The mechanism underlying perforin (PFN)-dependent delivery of apoptotic granzymes
during cytotoxic cell granule-mediated death remains speculative. Granzyme B (GrB) and …

The tumor necrosis factor (TNF) can induce apoptosis in many cells including MCF-7 cells.
To identify the genes responsible for TNF-induced apoptosis, we generated a series of TNF …

Natural killer and T cell-mediated cytotoxicity is important for the elimination of viruses and
transformed cells. The granule lytic pathway utilizes perforin and granzymes to induce cell …