Eighteen-month-old Sprague–Dawley rats present age-related alterations in lipid and
glucose metabolism and are resistant to the effect of PPARα-activating hypolipidemic drugs …

Hormesis refers to the beneficial effects of a treatment that at a higher intensity is harmful. In
one form of hormesis, sublethal exposure to stressors induces a response that results in …

Mouse-sized naked mole-rats (Heterocephalus glaber), unlike other mammals, do not
conform to Gompertzian laws of age-related mortality; adults show no age-related change in …

Of the multiple theories to explain exceptional longevity, the most robust of these has
centered on the reduction of three anabolic protein hormones, growth hormone (GH), insulin …

Abstract The NIH Summit, Advances in Geroscience: Impact on Health Span and Chronic
Disease, discusses several aspects of cellular degeneration that underlie susceptibility to …

Ames dwarf mice (Prop1df/df) and Little mice (Ghrhrlit/lit) are used as models of delayed
aging and show significant increases in lifespan (50% and 25%, respectively) when …

Average and maximal lifespan are important biological characteristics of every species, but
can be modified by mutations and by a variety of genetic, dietary, environmental, and …

To gain insight into the pathways by which caloric restriction (CR) slows aging, gene
expression levels were assessed for each of 2352 genes in the livers of 9-month-old CR and …

The investigation of age-induced disease progression in humans is time consuming and
resource intensive. One burning question for the exploration of human metabolic ageing is …

Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife
hepatic gene expressions in mice under different dietary conditions, which resulted in …