The role of macrophages in the infarcted myocardium: orchestrators of ECM remodeling

SA O'Rourke, A Dunne, MG Monaghan - Frontiers in cardiovascular …, 2019 - frontiersin.org
Myocardial infarction is the most common form of acute cardiac injury attributing to heart
failure. While there have been significant advances in current therapies, mortality and …

Myocardial infarction: a critical role of macrophages in cardiac remodeling

T Weinberger, C Schulz - Frontiers in physiology, 2015 - frontiersin.org
Ischemic heart disease is a common condition and a leading cause of mortality and
morbidity. Macrophages, besides their role in host defense and tissue homeostasis, are …

Monocyte and macrophage contributions to cardiac remodeling

M Hulsmans, F Sam, M Nahrendorf - Journal of molecular and cellular …, 2016 - Elsevier
The mammalian heart contains a population of resident macrophages that expands in
response to myocardial infarction and hemodynamic stress. This expansion occurs likely …

Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction

W Zuo, R Sun, Z Ji, G Ma - Cellular & Molecular Biology Letters, 2023 - Springer
Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Cardiac macrophages and their role in ischaemic heart disease

S Frantz, M Nahrendorf - Cardiovascular research, 2014 - academic.oup.com
Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI).
Different macrophage phenotypes likely promote myocardial health vs. disease. Infarct …

Crosstalk between macrophages and cardiac cells after myocardial infarction

Y Jian, X Zhou, W Shan, C Chen, W Ge, J Cui… - Cell Communication and …, 2023 - Springer
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death
worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing …

Macrophages in cardiac remodelling after myocardial infarction

J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature Reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Macrophages in myocardial infarction

A Kubota, NG Frangogiannis - American Journal of …, 2022 - journals.physiology.org
The heart contains a population of resident macrophages that markedly expands following
injury through recruitment of monocytes and through proliferation of macrophages. In …

[HTML][HTML] Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

Y Ma, AJ Mouton, ML Lindsey - Translational Research, 2018 - Elsevier
Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

Role of macrophages in cardioprotection

J Yap, HA Cabrera-Fuentes, J Irei… - International journal of …, 2019 - mdpi.com
Cardiovascular diseases are the leading cause of mortality worldwide. It is widely known
that non-resolving inflammation results in atherosclerotic conditions, which are responsible …