This paper reviews the current state of the use of organotypic brain slice cultures for
neurotoxicological and neuropharmacological screening and mechanistic studies, as …

Adequate tissue sampling is known to reduce the likelihood that the toxicity of novel
biomolecules, chemicals, and drugs might go undetected. Each organ, and often specific …

The need for biologically based, quantitative risk assessment procedures for noncancer
endpoints such as neurotoxicity has been discussed in reports by the United States …

A large number of chemicals may exert adverse effects on the central and/or peripheral
nervous system. A commonly recommended strategy for neurotoxicity testing is that of a …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a
test battery covering most of the relevant adverse outcome pathways may close this gap …

Neurotoxicologists have traditionally considered xeno-biotic-induced nervous tissue
dysfunction as a consequence of altered neuron activity. In contrast, glial cell involvement …

There is an urgent need for new in vitro strategies to identify neurotoxic agents with speed,
reliability and respect for animal welfare. Cell models should include distinct brain cell types …

Neurotoxlns represent unique chemical tools, providing a means to 1) gain insight into
cellular mechanisms of apopotosis and necrosis, 2) achieve a morphological template for …

A critical element of any experimental design is the selection of the model that will be used
to test the hypothesis. As Claude Bernard proposed over 100 years ago “the solution of a …