BACKGROUND Airway wall thickening has been observed in post mortem studies of
patients with asthma. Assessment of airway wall thickening by high resolution computed …

Postmortem studies have shown that airway wall thickening is present in asthmatic patients
and may play a pathophysiologic role. We investigated the presence and characteristics of …

Background: In some patients chronic asthma results in irreversible airflow obstruction. High
resolution computed tomography (HRCT) has been advocated for assessing the structural …

Background To prospectively apply an automated, quantitative three-dimensional approach
to imaging and airway analysis to assess airway remodeling in asthma patients. Methods …

Exaggerated airway narrowing in response to bronchoconstricting stimuli is a characteristic
feature of asthmatic subjects. It is unknown whether the site of airway narrowing differs in …

Airway wall thickening has been assumed to cause airway hyperresponsiveness, but a
protective effect against airway narrowing has also been suggested. We investigated the …

PURPOSE: To design and validate a dedicated software tool to measure airway dimensions
on thin-section computed tomographic (CT) images and to use the tool to prospectively …

The aim of this study was to examine the relationship between the structural changes in
large and small airways in asymptomatic asthmatics quantified by high-resolution computed …

Background: The epithelial reticular basement membrane (Rbm) of the airway wall thickens
in patients with asthma. However, whether the thickening parallels whole airway wall …

Asthma and COPD are the most prevalent of lung diseases and contribute an enormous
burden of morbidity in North America and globally. In both conditions, inflammation leads to …