Background CC chemokine receptor (CCR) 7 is a regulator of dendritic cell and T cell
migration, and its role in tissue wound healing has been investigated in various disease …

The aim of the present study was to evaluate the effects of the CC chemokine receptor
(CCR) 2b and CCR1 antagonist RS504393 as well as the roles of CCRs on …

Various CC chemokine receptors are expressed on effector cells in allergic inflammation
and their distinct expression pattern may dictate, to a large extent, the migration of …

To evaluate the significance of C–C chemokine receptor type 5 (CCR5) in lung tumor
development, we compared carcinogen-induced tumor growth in CCR5 knockout …

Accumulating evidence suggests that fibrosis is a multicellular process with contributions
from alveolar epithelial cells (AECs), recruited monocytes/macrophages, and fibroblasts. We …

The pathogenesis of bronchopulmonary dysplasia (BPD), involves inflammatory,
mechanisms that are not fully characterized. Here we report that overexpression of CC …

Background Idiopathic pulmonary fibrosis (IPF) is a chronically progressive interstitial lung
disease of unknown etiology. Previously, we have demonstrated the selective upregulation …

Elevated pulmonary levels of CCL18 have been associated with influx of T lymphocytes,
collagen accumulation, and a decline in lung function in pulmonary fibrosis patients. We …

Apoptosis of lung structural cells is crucial in the process of normal tissue repair. Insufficient
apoptosis of lung fibroblasts may contribute to the development of fibrosis. Since the CC …

Pulmonary fibrosis can be modeled in animals by intratracheal instillation of FITC, which
results in acute lung injury, inflammation, and extracellular matrix deposition. We have …