Increasing evidence suggests that the development of pulmonary fibrosis is a Th2-mediated
process. We hypothesized that the CC chemokines that are associated with a Th2 profile …

The CC chemokine ligand-2 (CCL2) and its receptor CCR2 are essential for monocyte
trafficking under inflammatory conditions. However, the mechanisms that determine the …

We previously showed increased expression of the ELR+, CXC chemokines in the lung after
left pulmonary artery obstruction. These chemokines have been shown in other systems to …

Acute respiratory distress syndrome (ARDS) consists of uncontrolled inflammation that
causes hypoxemia and reduced lung compliance. Since it is a complex process, not all …

The immune response to influenza A virus is characterized by an influx of both macrophages
and T lymphocytes into the lungs of the infected host, accompanied by induced expression …

Chemokines coordinate lung inflammation and fibrosis by acting on chemokine receptors
expressed on leukocytes and other cell types. Atypical chemokine receptors (ACKRs) bind …

Chemokines are key mediators of leukocyte recruitment during pathogenic insult and also
play a prominent role in homeostasis. While most chemokine receptors bind to multiple …

Idiopathic interstitial pneumonias (IIPs) are a collection of pulmonary fibrotic diseases of
unknown etiopathogenesis. CC chemokine receptor 7 (CCR7) is expressed in IIP biopsies …

The CC chemokine ligand 2 (CCL2)(JE, monocyte chemotactic protein-1 [MCP-1]) and its
CC chemokine receptor 2 (CCR2) are critical regulators of monocyte/macrophage trafficking …

A CC chemokine, CCL18, has been previously reported to stimulate collagen production in
pulmonary fibroblasts. This study focused on the role of protein kinase C (PKC) in the …