Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes
D Ziegler, N Papanas, A Zhivov, S Allgeier, K Winter… - Diabetes, 2014 - Am Diabetes Assoc
We sought to determine whether early nerve damage may be detected by corneal confocal
microscopy (CCM), skin biopsy, and neurophysiological tests in 86 recently diagnosed type …
microscopy (CCM), skin biopsy, and neurophysiological tests in 86 recently diagnosed type …
[HTML][HTML] Corneal nerve fractal dimension: a novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy
Objective: Corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, is a
noninvasive and objective imaging biomarker for identifying small nerve fiber damage. We …
noninvasive and objective imaging biomarker for identifying small nerve fiber damage. We …
[HTML][HTML] Corneal confocal microscopy differentiates inflammatory from diabetic neuropathy
M Fleischer, I Lee, F Erdlenbruch, L Hinrichs… - Journal of …, 2021 - Springer
Background Immune-mediated neuropathies, such as chronic inflammatory demyelinating
polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic …
polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic …
[HTML][HTML] Artificial intelligence and corneal confocal microscopy: the start of a beautiful relationship
Corneal confocal microscopy (CCM) is a rapid non-invasive in vivo ophthalmic imaging
technique that images the cornea. Historically, it was utilised in the diagnosis and clinical …
technique that images the cornea. Historically, it was utilised in the diagnosis and clinical …
Corneal confocal microscopy detects severe small fiber neuropathy in diabetic patients with Charcot neuroarthropathy
Abstract Aims/Introduction The aim of the present study was to identify the extent of small
fiber neuropathy in diabetic patients with Charcot neuroarthropathy (CN). Materials and …
fiber neuropathy in diabetic patients with Charcot neuroarthropathy (CN). Materials and …
[HTML][HTML] Corneal confocal microscopy detects small nerve fibre damage in patients with painful diabetic neuropathy
A Kalteniece, M Ferdousi, S Azmi, WM Mubita… - Scientific reports, 2020 - nature.com
Neuropathic pain is believed to arise from damage to nociceptive C fibres in diabetic
neuropathy (DN). We have utilised corneal confocal microscopy (CCM) to quantify the …
neuropathy (DN). We have utilised corneal confocal microscopy (CCM) to quantify the …
An automatic tool for quantification of nerve fibers in corneal confocal microscopy images
We describe and evaluate an automated software tool for nerve-fiber detection and
quantification in corneal confocal microscopy (CCM) images, combining sensitive nerve …
quantification in corneal confocal microscopy (CCM) images, combining sensitive nerve …
Structure-function relationship between corneal nerves and conventional small-fiber tests in type 1 diabetes
GA Sivaskandarajah, EM Halpern, LE Lovblom… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE In vivo corneal confocal microscopy (IVCCM) has been proposed as a
noninvasive technique to assess small nerve fiber structural morphology. We investigated …
noninvasive technique to assess small nerve fiber structural morphology. We investigated …
[HTML][HTML] Early corneal cellular and nerve fiber pathology in young patients with type 1 diabetes mellitus identified using corneal confocal microscopy
Purpose: The aim of this study was to quantify epithelial, stromal, and endothelial cell
density, and subbasal nerve morphology in young patients with type 1 diabetes mellitus with …
density, and subbasal nerve morphology in young patients with type 1 diabetes mellitus with …
In vivo confocal microscopy of human corneal nerves in health, in ocular and systemic disease, and following corneal surgery: a review
DV Patel, CNJ McGhee - British Journal of Ophthalmology, 2009 - bjo.bmj.com
The exponential evolution of in vivo confocal microscopy (IVCM) has led to a significant
enhancement in our knowledge of the living cornea in both its physiological and …
enhancement in our knowledge of the living cornea in both its physiological and …