10598 Background: Pathogenic variants in germline cancer-predisposing genes (eg
BRCA1/2, PALB2) confer an increased risk for solid tumors but not de novo myeloid …

Background: PALB2, located on chromosome 16, plays a vital role in DNA damage repair as
a partner and localizer of BRCA2. PALB2 germline pathogenic variant has been known to …

PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and
to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers …

Abstract Introduction: The Partner and Localizer of BRCA2 (PALB2) is a DNA repair and
tumor suppressor protein that acts by stabilizing BRCA2, thereby mediating DNA repair and …

On the quest to find the genetic etiology within a family with multiple cancer diagnoses,
identification of a pathogenic variant through multigene panel testing is the initial step of …

1531 Background: Inherited PALB2 pathogenic variants are associated with an increased
lifetime risk for breast cancer development. However, the interpretation of numerous PALB2 …

Purpose PALB2 germline pathogenic variants are associated with increased breast cancer
risk and smaller increased risk of pancreatic and likely ovarian cancer. Resources for health …

Mutations in the PALB2 gene are responsible for a small but significant percentage of
cancer risks in familial breast and pancreatic cancer families. PALB2 mutations may be …

PALB2 gene is mutated in about 1–2% of familial breast cancer as well as in 3–4% of
familial pancreatic cancer cases. Few studies have reported mutations in Italian patients with …

10528 Background: Tumor-genomic testing is increasingly used to guide treatment
decisions in cancer patients. Although tumor-only testing cannot definitively distinguish …