Semaphorin signaling in cancer cells and in cells of the tumor microenvironment–two sides of a coin
L Capparuccia, L Tamagnone - Journal of cell science, 2009 - journals.biologists.com
Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …
initially implicated in the development of the nervous system and in axon guidance. More …
Semaphorins in cancer: biological mechanisms and therapeutic approaches
M Rehman, L Tamagnone - Seminars in cell & developmental biology, 2013 - Elsevier
The hallmarks of cancer include multiple alterations in the physiological processes occurring
in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These …
in normal tissues, such as cell proliferation, apoptosis, and restricted cell migration. These …
The emerging role of class-3 semaphorins and their neuropilin receptors in oncology
P Nasarre, RM Gemmill, HA Drabkin - OncoTargets and therapy, 2014 - Taylor & Francis
The semaphorins, discovered over 20 years ago, are a large family of secreted or
transmembrane and glycophosphatidylinositol-anchored proteins initially identified as axon …
transmembrane and glycophosphatidylinositol-anchored proteins initially identified as axon …
The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
G Neufeld, O Kessler - Nature Reviews Cancer, 2008 - nature.com
The semaphorins and their receptors, the neuropilins and the plexins, were originally
characterized as constituents of the complex regulatory system responsible for the guidance …
characterized as constituents of the complex regulatory system responsible for the guidance …
Semaphorins and their receptors in lung cancer
VA Potiron, J Roche, HA Drabkin - Cancer letters, 2009 - Elsevier
Semaphorins are a large family of secreted, transmembrane and GPI-linked proteins initially
characterized in the development of the nervous system and axonal guidance. Semaphorins …
characterized in the development of the nervous system and axonal guidance. Semaphorins …
The role of semaphorins and their receptors in vascular development and cancer
C Gu, E Giraudo - Experimental cell research, 2013 - Elsevier
Semaphorins (Semas) are a large family of traditional axon guidance molecules. Through
interactions with their receptors, Plexins and Neuropilins, Semas play critical roles in a …
interactions with their receptors, Plexins and Neuropilins, Semas play critical roles in a …
Semaphorins and tumor angiogenesis
G Serini, F Maione, F Bussolino - Angiogenesis, 2009 - Springer
Semaphorins belong to a large family of proteins well-conserved along evolution from
viruses to mammalians. Secreted and membrane-bound semaphorins participate in a wide …
viruses to mammalians. Secreted and membrane-bound semaphorins participate in a wide …
Semaphorin receptors meet receptor tyrosine kinases on the way of tumor progression
G Cagnoni, L Tamagnone - Oncogene, 2014 - nature.com
Semaphorins are extracellular signals known to guide migrating cells during developmental
morphogenesis and in adult tissues. Semaphorin receptors, that is plexins and neuropilins …
morphogenesis and in adult tissues. Semaphorin receptors, that is plexins and neuropilins …
[HTML][HTML] Semaphorins as emerging clinical biomarkers and therapeutic targets in cancer
R Mastrantonio, H You, L Tamagnone - Theranostics, 2021 - ncbi.nlm.nih.gov
Semaphorins are a large family of developmental regulatory signals, characterized by
aberrant expression in human cancers. These molecules crucially control cell-cell …
aberrant expression in human cancers. These molecules crucially control cell-cell …
The role of the semaphorins in cancer
G Neufeld, Y Mumblat, T Smolkin… - Cell Adhesion & …, 2016 - Taylor & Francis
The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …
subsequently been implicated also in the regulation of immune responses, angiogenesis …