The synergic effect of luminal Ca2+, cytosolic Ca2+, and cytosolic adenosine triphosphate
(ATP) on activation of cardiac ryanodine receptor (RYR2) channels was examined in planar …

Cardiac ryanodine receptors (RYR2s) infrequently exhibit coupled gating that is manifested
by synchronous opening and closing. To better characterize this phenomenon, we …

The sarcoplasmic reticulum (SR) calcium release channel, also known as the ryanodine
receptor (RyR), is an essential component of excitation-contraction (EC) coupling in striated …

Voltage-dependent modulation of cardiac ryanodine receptors (RyR2) was studied in planar
lipid bilayers. Different earth alkaline cations (M 2+: Mg 2+, Ca 2+, Sr 2+, Ba 2+) were …

The biological methyl group donor, S-adenosyl-L-methionine (SAM) activates the cardiac
ryanodine receptor (RyR2). Previously we investigated the mechanism underlying SAM …

Abstract Activity of the Ryanodine Receptor (RyR2)(aka cardiac Ca2+ release channel)
plays a pivotal role in contraction of the heart. S-adenosyl-l-methionine (SAM) is a biological …

The cardiac ryanodine receptor (RyR2) mediates Ca 2+ efflux from intracellular stores to
effect myocyte contraction during excitation-contraction coupling. Mutations in this channel …

Prior observations have raised the possibility that dihydropyridine (DHP) agonists directly
affect the sarcoplasmic reticulum (SR) cardiac Ca2+ release channel [ie, ryanodine receptor …

In previous studies, we have demonstrated that the interaction of ryanoids with the
sarcoplasmic reticulum Ca2+-release channel [ryanodine receptor (RyR)] incorporated into …

Maurocalcine (MCa) is a 33-amino acid peptide isolated from the venom of Scorpio maurus
palmatus, a Tunisian scorpion. It possesses efficient cell penetration properties and has …