The type 2 ryanodine receptor (RyR2) is the major sarcoplasmic reticulum (SR) Ca release
channel in cardiomyocytes. Mutation mappings have revealed a functional importance of the …

Iron is examined for its ability to modify Ca2+ transport across sarcoplasmic reticulum (SR)
and to alter the binding of [3H] ryanodine to its high-affinity site on the Ca2+ release channel …

The cardiac type 2 ryanodine receptor (RYR2) is activated by Ca2+-induced Ca2+ release
(CICR). The inherent positive feedback of CICR is well controlled in cells, but the nature of …

The cardiac ryanodine receptor (RyR2) is the major calcium (Ca 2+) release channel on the
sarcoplasmic reticulum (SR) in cardiomyocytes. The RYR2 gene encodes a large∼ 565 kDa …

Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca2+ and Mg2+ plays a
key role in determining cardiac contraction and rhythmicity, but their role in regulating the …

Cryo-electron micrograph studies recently have identified a Ca 2+-binding site in the 2,200-
kDa ryanodine receptor ion channel (RyR1) in skeletal muscle. To clarify the role of this site …

We have developed a novel technique for incorporation of sheep cardiac sarcoplasmic
reticulum (SR) Ca2+-release channels into planar phospholipid bilayers in order to …

Publisher Summary Signal Ca 2+ enters the cytoplasm of mammalian cells from either
extracellular space or the lumenal space of intracellular organelles, the source depending …

Cardiac contraction is initiated by Ca2+ leaving the sarcoplasmic reticulum through the
ryanodine receptor (RyR). Although opening of the RyR can be modified by various ligands …

RyR (ryanodine receptors) are integral membrane proteins, localized primarily to the
membrane of the junctional sarcoplasmic reticulum (SR). Their topology is asymmetrical in …