The interaction of ryanodine and derivatives of ryanodine with the high affinity binding site
on the ryanodine receptor (RyR) channel brings about a characteristic modification of …

To clarify whether activity of the ryanodine receptor type 2 (RyR2) is reduced in the
sarcoplasmic reticulum (SR) of cardiac muscle, as is the case with the ryanodine receptor …

The objective of this work was to identify and further characterize potential changes in the
functional profile of the cardiac ryanodine receptor (RyR2) channel caused by the coupled …

Ryanodine receptors (RyR) are a class of Ca 2+-selective ion channels located in the
intracellular membrane systems (sarcoplasmic reticulum and endoplasmic reticulum) of …

Abstract Ryanodine Receptors (RyRs) are complex proteins embedded in the membranes of
the endoplasmic and sarcoplasmic reticulum. They dictate the release of one of the most …

Abstract Ryanodine receptors type 2 (RyR2) regulate excitation-contraction coupling. Their
dysfunction leads to pathological states, such as arrhythmia, heart failure and sudden death …

A fragment of RyR1 (amino acids 4064–4210) is predicted to fold to at least one lobe of
calmodulin and to bind Ca 2+. This fragment of RyR1 (R4064–4210) was subcloned …

The cardiac ryanodine receptor has become a subject of increasing interest as its role in the
etiology of cardiac disease is becoming more apparent. In this article, we review the current …

ATP is an essential constitutive regulator of cardiac ryanodine receptors (RyR2), enabling
small changes in cytosolic Ca2+ to trigger large changes in channel activity. With recent …

Skeletal (RyR1) and cardiac muscle (RyR2) isoforms of ryanodine receptor calcium
channels are inhibited by millimollar Ca2+, but the affinity of RyR2 for inhibitory Ca2+ is∼ …