In vitro tumor models have played vital roles in enhancing the understanding of the cellular
and molecular composition of tumors, as well as their biochemical and biophysical …

Cancer is one of the leading causes of death worldwide, despite the large efforts to improve
the understanding of cancer biology and development of treatments. The attempts to …

Traditional in vitro and in vivo models typically used in cancer research have demonstrated
a low predictive power for human response. This leads to high attrition rates of new drugs in …

This chapter summarizes the current biomaterials and associated technologies used to
mimic and characterize the tumor microenvironment (TME) for developing preclinical …

The tumor microenvironment (TME) plays a critical, yet mechanistically elusive role in tumor
development and progression, as well as drug resistance. To better understand the …

Tumors are a major cause of death worldwide, and much effort has been made to develop
appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the …

Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …

Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the
tumour microenvironment and allow for the study of dynamic interactions that occur during …

Cancer treatment is challenged by the heterogeneous nature of cancer, where prognosis
depends on tumor type and disease stage, as well as previous treatments. Optimal patient …