Physical state and biological activity of human papillomavirus genomes in precancerous lesions of the female genital tract

H Lehn, LL Villa, F Marziona… - Journal of General …, 1988 - microbiologyresearch.org
The DNA of distinct human papillomaviruses (HPVs) is regularly detected in the majority of
human cervical carcinomas. In contrast to benign HPV-induced genital lesions, where the …

Analysis of HPV16, 18, 31, and 35 DNA in pre-invasive and invasive lesions of the uterine cervix.

L Pirami, V Giache, A Becciolini - Journal of clinical pathology, 1997 - jcp.bmj.com
AIMS: To analyse the physical state of different human papillomavirus (HPV) DNAs in 55
intraepithelial and invasive HPV associated cervical neoplasms. METHODS: Restriction …

Physical status and expression of HPV genes in cervical cancers

JS Park, ES Hwang, SN Park, HK Ahn, SJ Um… - Gynecologic …, 1997 - Elsevier
It is known that E2 protein of oncogenic human papillomavirus (HPV) inhibits the expression
of E6 and E7 genes from their major promotersin vitroand suppresses the proliferation of …

Analysis by polymerase chain reaction of the physical state of human papillomavirus type 16 DNA in cervical preneoplastic and neoplastic lesions

BC Das, JK Sharma… - Journal of General …, 1992 - microbiologyresearch.org
Integration of human papillomavirus (HPV) DNA into the host cell genome is believed to be
essential for malignant progression. However unambiguous detection of the physical state of …

Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm

AP Cullen, R Reid, M Campion, AT Lörincz - Journal of virology, 1991 - Am Soc Microbiol
The integration of human papillomavirus (HPV) DNA into the human genome has been
generally accepted as a characteristic of malignant lesions. To gain a better understanding …

Thes physical state of human papillomavirus 16 DNAxs in cervical carcinoma and cervical intraepithelial neoplasia

M Fukushima, Y Yamakawa, S Shimano… - Cancer, 1990 - Wiley Online Library
Cervical carcinomas and cervical intraepithelial neoplasias (CIN) were analyzed for the
presence of human papillomavirus (HPV) DNA using Southern blot hybridization. of the five …

Both episomal and integrated forms of human papillomavirus type 16 are involved in invasive cervical cancers

T Matsukura, S Koi, M Sugase - Virology, 1989 - Elsevier
The form of human papillomavirus type 16 (HPV 16) DNA in specimens of invasive cervical
cancer was investigated. High molecular, tandem repeats of viral sequences were detected …

Physical state of HPV16 and chromosomal mapping of the integrated form in cervical carcinomas

M Kalantari, E Blennow, B Hagmar… - Diagnostic Molecular …, 2001 - journals.lww.com
Using a procedure based on restriction enzyme cleavage, self-ligation, and inverse
polymerase chain reaction (rli PCR), the authors investigated 18 cervical intraepithelial …

Physical state and expression of HPV DNA in benign and dysplastic cervical tissue: different levels of viral integration are correlated with lesion grade

G Hudelist, M Manavi, KID Pischinger… - Gynecologic …, 2004 - Elsevier
Objective. Human papillomavirus (HPV) infection is the most important event in the
malignant transformation of human cervical epithelium. Several high-risk (HR-) HPV …

Analysis of integrated human papillomavirus type 16 DNA in cervical cancers: amplification of viral sequences together with cellular flanking sequences

M Wagatsuma, K Hashimoto, T Matsukura - Journal of virology, 1990 - Am Soc Microbiol
We have isolated four clones of integrated human papillomavirus type 16 (HPV-16) DNA
from four different primary cervical cancer specimens. All clones were found to be …