Phytocannabinoids biosynthesis during early stages of development of young Cannabis sativa L. seedlings: Integrating biochemical and transcription data

F Fulvio, G Mandolino, C Citti, N Pecchioni… - Phytochemistry, 2023 - Elsevier
Cannabis sativa (L.) is characterized by great genetic and phenotypic diversity, also
expressed in the array of bioactive compounds synthesized. Despite its great potential …

[HTML][HTML] Analysis of Sequence Variability and Transcriptional Profile of Cannabinoid synthase Genes in Cannabis sativa L. Chemotypes with a Focus on …

F Fulvio, R Paris, M Montanari, C Citti, V Cilento… - Plants, 2021 - mdpi.com
Cannabis sativa L. has been long cultivated for its narcotic potential due to the accumulation
of tetrahydrocannabinolic acid (THCA) in female inflorescences, but nowadays its …

[HTML][HTML] Evolution, genetics and biochemistry of plant cannabinoid synthesis: a challenge for biotechnology in the years ahead

R Melzer, PF McCabe, S Schilling - Current Opinion in Biotechnology, 2022 - Elsevier
Cannabis sativa is most prominent for its psychoactive secondary compound
tetrahydrocannabinol, or THC. However, THC is only one of many phytocannabinoids found …

Cannabinoids: biosynthesis and biotechnological applications

S Sirikantaramas, F Taura - Cannabis sativa L.-Botany and biotechnology, 2017 - Springer
Cannabinoids are unique terpenophenolic metabolites found only in Cannabis sativa. The
biosynthetic mechanism of these compounds had long been ambiguous since conventional …

Sequence heterogeneity of cannabidiolic-and tetrahydrocannabinolic acid-synthase in Cannabis sativa L. and its relationship with chemical phenotype

C Onofri, EPM de Meijer, G Mandolino - Phytochemistry, 2015 - Elsevier
Sequence variants of THCA-and CBDA-synthases were isolated from different Cannabis
sativa L. strains expressing various wild-type and mutant chemical phenotypes …

[HTML][HTML] Profiling Cannabinoid Contents and Expression Levels of Corresponding Biosynthetic Genes in Commercial Cannabis (Cannabis sativa L.) Cultivars

AL Kim, YJ Yun, HW Choi, CH Hong, HJ Shim, JH Lee… - Plants, 2022 - mdpi.com
Cannabis (Cannabis sativa L.) is widely cultivated and studied for its psychoactive and
medicinal properties. As the major cannabinoids are present in acidic forms in Cannabis …

[HTML][HTML] Highly Predictive Genetic Markers Distinguish Drug-Type from Fiber-Type Cannabis sativa L

F Cascini, A Farcomeni, D Migliorini, L Baldassarri… - Plants, 2019 - mdpi.com
Genetic markers can be used in seeds and in plants to distinguish drug-type from fiber-type
Cannabis Sativa L. varieties even at early stages, including pre-germination when …

[HTML][HTML] Hormonal control of promoter activities of Cannabissativa prenyltransferase 1 and 4 and salicylic acid mediated regulation of cannabinoid biosynthesis

LB Sands, SR Haiden, Y Ma, GA Berkowitz - Scientific Reports, 2023 - nature.com
Cannabis sativa aromatic prenyltransferase 4 (CsPT4) and 1 (CsPT1) have been shown to
catalyze cannabigerolic acid (CBGA) biosynthesis, a step that rate-limits the cannabinoid …

Signaling compounds elicit expression of key genes in cannabinoid pathway and related metabolites in cannabis

S Jalali, SA Salami, M Sharifi, S Sohrabi - Industrial Crops and Products, 2019 - Elsevier
The potential for product recovery of metabolites can be improved by several methods; one
of the most common techniques is elicitation. Elicitors can adjust multiple control points and …

Delineating genetic regulation of cannabinoid biosynthesis during female flower development in Cannabis sativa

PV Apicella, LB Sands, Y Ma, GA Berkowitz - Plant Direct, 2022 - Wiley Online Library
Cannabinoids are predominantly produced in the glandular trichomes on cannabis female
flowers. There is little known on how cannabinoid biosynthesis is regulated during female …