Determination of 5-fluorouracil in human plasma by high-performance liquid chromatography (HPLC)

Y Gu, R Lu, D Si, C Liu - Transactions of Tianjin University, 2010 - Springer
Fluorouracil (5-FU) has a broad spectrum of anti-tumor activity, widely applied to the
treatment of cancers. However, it is necessary to determine the plasma concentration of 5 …

Simple and sensitive determination of 5-fluorouracil in plasma by high-performance liquid chromatography: Application to clinical pharmacokinetic studies

J Escoriaza, A Aldaz, E Calvo, J Giraldez - Journal of Chromatography B …, 1999 - Elsevier
5-Fluorouracil (5-FU) is an antineoplastic agent widely employed in the treatment of many
types of cancer. Recent studies have proved the need for individual adjustment of 5-FU …

An HPLC method for the measurement of 5-fluorouracil in human plasma with a low detection limit and a high extraction yield

MA Nassim, FH Shirazi, CM Cripps… - International …, 2002 - spandidos-publications.com
High performance liquid chromatographic (HPLC) techniques for the quantification of 5-
fluorouracil (5-FU) in human plasma have been reported in the literature, however, a low …

Determination of 5-fluorouracil in human plasma by a simple and sensitive reversed-phase HPLC method

RA Coe, RA Earl, TC Johnson, JW Lee - Journal of pharmaceutical and …, 1996 - Elsevier
A simple and sensitive reversed-phase HPLC method with UV detection was developed and
validated for the quantitation of 5-fluorouracil (5-FU) in human plasma. After acidification and …

Simple high-performance liquid chromatographic method for the quantitation of 5-fluorouracil in human plasma

P Compagnon, L Thiberville, N Moore… - … of Chromatography B …, 1996 - Elsevier
A simple, rapid, specific and sensitive high-performance liquid chromatography method has
been developed for quantitation of 5-fluorouracil (5-FU) in human plasma. The method …

Determination of 5-fluorouracil in 5-fluorouracil injection and human serum by HPLC

L Zhu, GJ Shen, SQ Ding, XIN Hua - Journal of Food and Drug …, 2012 - jfda-online.com
A high-performance liquid chromatography (HPLC) method was developed for the
determination of 5-fluorouracil (5-FU) in 5-FU injection and human serum. A Nova-park C18 …

Development of a HPLC method to determine 5-fluorouracil in plasma: application in pharmacokinetics and steady-state concentration monitoring.

C Pi, Y Wei, H Yang, Y Zhou, J Fu, S Yang… - … journal of clinical …, 2014 - europepmc.org
A simple, rapid and sensitive high-power liquid chromatographic (HPLC) method for
analysis of 5-fluorouracil (5-FU) in patient plasma was developed and validated to study …

Determination of 5-fluorouracil in plasma and whole blood by ion-pair high-performance liquid chromatography

AM Rustum, NE Hoffman - … of Chromatography B: Biomedical Sciences and …, 1988 - Elsevier
Fluorouracil in blood or plasma was determined by extraction and column liquid
chromatography. Acetonitrile was added to blood or plasma and the mixture was stirred and …

Simultaneous determination of 5-fluorouracil and uracil by high-performance liquid chromatography using four serial columns

LK House, J Ramı́rez, MJ Ratain - Journal of Chromatography B …, 1998 - Elsevier
A sensitive assay was developed for the quantitation of 5-fluorouracil (5-FU) and uracil using
liquid–liquid extraction (LLE) and HPLC with UV detection. Analyses were performed with …

Quantitative analysis of 5-fluorouracil in human serum by high-performance liquid chromatography

MW DeGregorio, WM Holleran, CC Benz… - Analytical …, 1985 - Taylor & Francis
A modified ion pair reverse-phase high-performance liquid chromatographic (HPLC) method
for examining 5-fluorouracil levels in human serum was developed. The method employs …