We studied the effects of positive end-expiratory pressure (PEEP)(2 to 14 cm H 2 O) on
alveolar recruitment (Vrec), static respiratory compliance, and end-expiratory lung volume …

Acute respiratory distress syndrome, a diagnosis based on physiologic and radiological
criteria, occurs commonly in critical care setting. A major challenge in evaluating therapies …

The use of low tidal volume ventilation and low to moderate positive end-expiratory pressure
(PEEP) levels is a widespread strategy to ventilate patients with non-injured lungs during …

Despite recent advances in intensive care medicine, acute lung injury and its more severe
form, acute respiratory distress syndrome pose major therapeutic problems. While …

Objectives: The Berlin definition of acute respiratory distress syndrome has introduced three
classes of severity according to PaO 2/FIO 2 thresholds. The level of positive end-expiratory …

Objectives: To evaluate the outcome in patients with severe adult respiratory distress
syndrome (ARDS) managed with limitation of peak inspiratory pressure to 30 to 40 cm H 2 …

Acute respiratory distress syndrome (ARDS) patients need mechanical ventilation to sustain
gas exchange. Animal experiments showed that mechanical ventilation with high …

Airway pressure release ventilation (APRV) was originally described as a mode to treat lung-
injured patients with the goal to maintain a level of airway pressure that would not depress …

Objective. Reduction in tidal volume (Vt) associated with increase in respiratory rate to limit
hypercapnia is now proposed in patients with acute lung injury (ALI). The aim of this study …

The evidence supports the idea that mechanical ventilation can potentially cause further
lung injury. The only ventilator manipulation that so far has been shown definitively to …