Opioid receptors are important drug targets for pain management, addiction, and mood
disorders. Although substantial research on these important subtypes of G protein-coupled …

Twelve years after the publication of the first crystal structure of a G-protein-coupled receptor
(GPCR), experimental crystal structures of the four opioid receptor subtypes have made their …

Mu opioid receptor agonists are among the most powerful analgesic medications but also
among the most addictive. The current opioid crisis has energized a quest to develop opioid …

Opioids such as morphine and oxycodone are analgesics frequently prescribed for the
treatment of moderate or severe pain. Unfortunately, these medications are associated with …

Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

Opiate drugs mediate their analgesic, euphoriant, and rewarding effects by activating opioid
receptors. Pharmacological and molecular studies have demonstrated the existence of three …

The use of opioid analgesics for pain has always been hampered by their many side effects;
in particular, the addictive liability associated with chronic use. Recently, attempts to develop …

As a whole, the G protein-coupled receptor (GPCR) superfamily displays no overall
sequence homology. Nevertheless, enough short sequences and even individual amino …

It is now about 40 years since Avram Goldstein proposed the use of the stereoselectivity of
opioid receptors to identify these receptors in neural membranes. In 2012, the crystal …

The opioid receptors are among the most highly studied members of the family of G protein-
coupled receptors. As for many other members of this family, recent studies have indicated …