Bacterial endocarditis is a difficult-to-curc infection, owing to (i) poor penetration of
antibiotics into infected vegetations;(ii) altered metabolic state of bacteria within the …

The reproduction in animals of an infectious process close to those encountered in humans
may be very useful for several reasons. The human infection may be rare but severe, so …

The experimental animal model of endocarditis provides a rigorous test of antibiotic efficacy.
It is a reliable, easily reproducible model of severe infection which requires high in vivo …

It WAS about 100 yr ago that bacteria were identified as the cause of infective endocarditis.
Subsequently, there was a long period of clinical observation, during which time the natural …

The main objective of medical treatment of infective endocarditis is to sterilize the vegetative
lesions characteristic of the disease. The general principles of treatment are:(1) identification …

Intravascular or cardiac endothelial lesions may become colonized during bacteraemic
episodes and lead to the development of bacterial endocarditis (BE). It has therefore long …

Three aspects of our current understanding of the pathogenesis of infective endocarditis are
reviewed: the size of the infected vegetation, host defence mechanisms and conditions …

Numerous important observations concerning the pathogenesis of infective endocarditis
have been made over the past 18 years. Many of these observations have been obtained …

Animal models are commonly used to determine the efficacy of various antimicrobial agents
for treatment of bacterial endocarditis. Previously we have utilized an in vitro infection model …

The results of studies performed with animal models of experimental infective endocarditis
have provided valuable information about the pathophysiology, natural history, and …