Myostatin (Mstn) participates in the regulation of skeletal muscle size and has emerged as a
regulator of muscle metabolism. Here, we hypothesized that lack of myostatin profoundly …

The progressive loss of skeletal muscle mass, strength and/or function with advancing age,
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …

Skeletal muscle possesses the ability to both respond and adapt to changing environmental
stimuli, leading to a set of metabolic and morphological adaptations, which allow it to better …

A decade has passed since myostatin was first identified as a negative regulator of muscle
growth. Since then, studies in both humans and animals have demonstrated that decreasing …

Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human
skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were …

Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …

Myostatin deficiency leads to both an increased rate of protein synthesis and skeletal muscle
hypertrophy. However, the mechanisms involved in mediating these effects are not yet fully …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Aim Some health benefits of exercise may be explained by an altered secretion of myokines.
Because previous focus has been on upregulated myokines, we screened for …

These studies suggest that proteins and drugs that inactivate myostatin, or interfere with its
binding to its receptor, may be useful for the therapy of wasting and degenerative muscle …