Myostatin is a highly conserved negative regulator of skeletal muscle growth. Loss of
functional myostatin in cattle, mice, sheep, dogs, and humans results in increased muscle …

The obesity epidemic is an overwhelming global health concern. Interventions to improve
body weight and composition aim to restore balance between nutrient intake and energy …

Obesity and type 2 diabetes mellitus have reached an epidemic level, thus novel treatment
concepts need to be identified. Myostatin, a myokine known for restraining skeletal muscle …

Myostatin is a negative regulator of skeletal muscle growth and in fact acts as a potent
inducer of “cachectic-like” muscle wasting in mice. The mechanism of action of myostatin in …

Objective Myostatin is a secreted growth factor expressed in skeletal muscle tissue, which
negatively regulates skeletal muscle mass. Recent animal studies suggest a role for …

Key points Myostatin is an important regulator of muscle mass and a potential therapeutic
target for the treatment of diseases and injuries that result in muscle atrophy. Targeted …

Myostatin (Mstn) is a secreted growth factor predominately expressed in skeletal muscle that
negatively regulates skeletal muscle mass. Recent studies have indicated that loss function …

Inhibitors of myostatin, a negative regulator of skeletal muscle mass, are being developed to
mitigate aging‐related muscle loss. Knock‐out (KO) mouse studies suggest myostatin also …

Although myostatin negatively regulates skeletal muscle growth, its function in heart is
virtually unknown. Herein we demonstrate that it inhibits basal and IGF‐stimulated …

Myostatin is a cytokine that has recently been shown to selectively and potently inhibit
myogenesis. To investigate the mechanisms of anabolic actions of GH on skeletal muscle …