Myostatin regulates both muscle mass and muscle metabolism. The myostatin null
(MSTN−/−) mouse has a hypermuscular phenotype owing to both hypertrophy and …

Mice and cattle with genetic deficiencies in myostatin exhibit dramatic increases in skeletal
muscle mass, suggesting that myostatin normally suppresses muscle growth. Whether this …

Myostatin, a member of the TGF-β family, has been identified as a master regulator of
embryonic myogenesis and early postnatal skeletal muscle growth. However, cumulative …

The natural aging process results in the physiological decline of multiple tissues and organ
systems. Changes commonly occur with middle age and include decreased skeletal muscle …

Myostatin is a highly conserved protein secreted primarily from skeletal muscle that can
potently suppress muscle growth. This ability to regulate skeletal muscle mass has sparked …

Myostatin is a newly described member of the TGF-β superfamily acting as a secreted
negative regulator of skeletal muscle mass in several species, but whose mode of action …

Human aging is accompanied by a progressive loss of muscle mass (sarcopenia). We tested
the hypothesis that older males (OMs, 70±4 yr, n= 9) would have a blunted myogenic …

Myostatin inhibits myogenesis and there is reduced abundance of the mature protein in
skeletal muscles of adult male compared with female mice. This reduction probably occurs …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Myostatin is a negative regulator of skeletal muscle growth and affects numerous genes
expression involved in cell proliferation, differentiation and metabolism. However, the …