[HTML][HTML] Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPARγ-ABCA1 pathway

L Sun, E Li, F Wang, T Wang, Z Qin… - International journal of …, 2015 - ncbi.nlm.nih.gov
The accumulation of cholesterol in macrophages could induce the formation of foam cells
and increase the risk of developing atherosclerosis. We wonder if quercetin, one of …

Quercetin up-regulates expressions of peroxisome proliferator-activated receptor γ, liver X receptor α, and ATP binding cassette transporter A1 genes and increases …

SM Lee, J Moon, Y Cho, JH Chung, MJ Shin - Nutrition Research, 2013 - Elsevier
Cholesterol-laden macrophages trigger accumulation of foam cells and increase the risk of
developing atherosclerosis. We hypothesized that quercetin could lower the content of …

Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins

W Dong, X Wang, S Bi, Z Pan… - International …, 2014 - spandidos-publications.com
Resveratrol has been shown to exert anti-atherosclerotic effects. 5'AMP-activated protein
kinase (AMPK) and monocyte chemotactic protein-1 (MCP-1) play key roles in foam cell …

Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway

S Franceschelli, F De Cecco, M Pesce, P Ripari… - International journal of …, 2023 - mdpi.com
Cholesterol accumulation in macrophages leads to the formation of foam cells and
increases the risk of developing atherosclerosis. We have verified whether hydroxytyrosol …

Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis

JF Zhao, LC Ching, YC Huang, CY Chen… - Molecular nutrition & …, 2012 - Wiley Online Library
Scope Curcumin, a potent antioxidant extracted from Curcuma longa, confers protection
against atherosclerosis, yet the detailed mechanisms are not fully understood. In this study …

Lysophosphatidylcholine promotes cholesterol efflux from mouse macrophage foam cells via PPARγ‐LXRα‐ABCA1‐dependent pathway associated with apoE

M Hou, M Xia, H Zhu, Q Wang, Y Li… - Cell biochemistry …, 2007 - Wiley Online Library
Formation of macrophage‐derived foam cells is a hallmark in earlier stages of
atherosclerosis (AS). Increased cholesterol efflux from macrophage foam cells promote …

[PDF][PDF] Quercetin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in THP-1 macrophages.

Y Lu, YP Jia - European Review for Medical & Pharmacological …, 2016 - europeanreview.org
OBJECTIVES: Quercetin has been reported to have the activities of antioxidant, anti-
inflammatory, anti-virus, anti-cancer and so on. Many studies showed that quercetin could …

Bioactive components to inhibit foam cell formation in atherosclerosis

S Singh, S Changkija, R Mudgal… - Molecular Biology …, 2022 - Springer
Background The production of lipid-laden cells in macrophages after significant ingestion of
oxidized low-density lipoprotein is considered the most critical phase in the creation of …

Diterpenoids inhibit ox-LDL-induced foam cell formation in RAW264. 7 cells by promoting ABCA1 mediated cholesterol efflux

C Zhang, X Wu, P Shi, H Ma, F Fang, Q Feng… - Frontiers in …, 2023 - frontiersin.org
Introduction: Atherosclerosis is the main cause of many cardiovascular diseases and
contributes to morbidity and mortality worldwide. The formation of macrophage-derived foam …

Berberine attenuates cholesterol accumulation in macrophage foam cells by suppressing AP-1 activity and activation of the Nrf2/HO-1 pathway

XJ Yang, F Liu, N Feng, XS Ding, Y Chen… - Journal of …, 2020 - journals.lww.com
Atherosclerosis is a chronic inflammation condition resulting from the interaction between
lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in …