Trauma-induced coagulopathy: from biology to therapy
P Noel, S Cashen, B Patel - Seminars in hematology, 2013 - Elsevier
Trauma is a leading cause of death and disability. Hemorrhage is the major mechanism
responsible for death during the first 24 hours following trauma. One quarter of severely …
responsible for death during the first 24 hours following trauma. One quarter of severely …
Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?
K Brohi, MJ Cohen, MT Ganter, MA Matthay… - Annals of …, 2007 - journals.lww.com
Objectives: Coagulopathy following major trauma is conventionally attributed to activation
and consumption of coagulation factors. Recent studies have identified an acute …
and consumption of coagulation factors. Recent studies have identified an acute …
Effects of C1 inhibitor on tissue damage in a porcine model of controlled hemorrhage
JJ Dalle Lucca, Y Li, M Simovic, AE Pusateri… - Shock, 2012 - journals.lww.com
Activation of the complement system has been associated with tissue injury after
hemorrhage and resuscitation in animals. We investigated whether administration of …
hemorrhage and resuscitation in animals. We investigated whether administration of …
The emerging role of vitamin C as a treatment for sepsis
MG Kashiouris, M L'Heureux, CA Cable, BJ Fisher… - Nutrients, 2020 - mdpi.com
Sepsis, a life-threatening organ dysfunction due to a dysregulated host response to
infection, is a leading cause of morbidity and mortality worldwide. Decades of research have …
infection, is a leading cause of morbidity and mortality worldwide. Decades of research have …
[HTML][HTML] Acidosis and correction of acidosis does not affect rFVIIa function in swine
DN Darlington, BS Kheirabadi, MR Scherer… - … Journal of Burns and …, 2012 - ncbi.nlm.nih.gov
Background: Hemorrhagic shock and trauma are associated with acidosis and altered
coagulation. A fall in pH has been reported to attenuate the activity of recombinant activated …
coagulation. A fall in pH has been reported to attenuate the activity of recombinant activated …
Coagulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation
AIMS: Identifying early changes in hemostatic clot function as a result of tissue injury and
hypoperfusion may provide important information regarding the mechanisms of traumatic …
hypoperfusion may provide important information regarding the mechanisms of traumatic …
Practical application of point-of-care coagulation testing to guide treatment decisions in trauma
H Schöchl, W Voelckel, A Grassetto… - Journal of Trauma and …, 2013 - journals.lww.com
Exsanguination is responsible for 30% to 40% of trauma-related deaths. 1, 2 Most of these
fatalities occur in the prehospital setting. According to standard coagulation tests (SCTs) …
fatalities occur in the prehospital setting. According to standard coagulation tests (SCTs) …
Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis
K Brohi, MJ Cohen, MT Ganter, MJ Schultz… - Journal of Trauma …, 2008 - journals.lww.com
Background: Coagulopathy is present at admission in 25% of trauma patients, is associated
with shock and a 5-fold increase in mortality. The coagulopathy has recently been …
with shock and a 5-fold increase in mortality. The coagulopathy has recently been …
Factor IX complex for the correction of traumatic coagulopathy
B Joseph, A Amini, RS Friese, M Houdek… - Journal of Trauma …, 2012 - journals.lww.com
BACKGROUND: Damage control resuscitation advocates correction of coagulopathy;
however, options are limited and expensive. The use of prothrombin complex concentrate …
however, options are limited and expensive. The use of prothrombin complex concentrate …
Increase in activated protein C mediates acute traumatic coagulopathy in mice
BB Chesebro, P Rahn, M Carles, CT Esmon, J Xu… - Shock, 2009 - journals.lww.com
In severely injured and hypoperfused trauma patients, endogenous acute coagulopathy
(EAC) is associated with an increased morbidity and mortality. Recent human data correlate …
(EAC) is associated with an increased morbidity and mortality. Recent human data correlate …