Trauma is a leading cause of death and disability. Hemorrhage is the major mechanism
responsible for death during the first 24 hours following trauma. One quarter of severely …

Objectives: Coagulopathy following major trauma is conventionally attributed to activation
and consumption of coagulation factors. Recent studies have identified an acute …

Activation of the complement system has been associated with tissue injury after
hemorrhage and resuscitation in animals. We investigated whether administration of …

Sepsis, a life-threatening organ dysfunction due to a dysregulated host response to
infection, is a leading cause of morbidity and mortality worldwide. Decades of research have …

Background: Hemorrhagic shock and trauma are associated with acidosis and altered
coagulation. A fall in pH has been reported to attenuate the activity of recombinant activated …

AIMS: Identifying early changes in hemostatic clot function as a result of tissue injury and
hypoperfusion may provide important information regarding the mechanisms of traumatic …

Exsanguination is responsible for 30% to 40% of trauma-related deaths. 1, 2 Most of these
fatalities occur in the prehospital setting. According to standard coagulation tests (SCTs) …

Background: Coagulopathy is present at admission in 25% of trauma patients, is associated
with shock and a 5-fold increase in mortality. The coagulopathy has recently been …

BACKGROUND: Damage control resuscitation advocates correction of coagulopathy;
however, options are limited and expensive. The use of prothrombin complex concentrate …

In severely injured and hypoperfused trauma patients, endogenous acute coagulopathy
(EAC) is associated with an increased morbidity and mortality. Recent human data correlate …