Traumatic injury is a significant cause of morbidity and mortality worldwide. Microcirculatory
activation and injury from hemorrhage contribute to organ injury. Many adaptive responses …

Background Plasma resuscitation ameliorates hyperfibrinolysis (HF) and trauma-induced
coagulopathy (TIC). However, the use of other blood components to reduce HF has not been …

Trauma remains the leading cause of death and disability in adults and is responsible for
more life lost and, more importantly, quality life lost than heart disease, human …

Background: Rapid resuscitation with oxygen-carrying fluids is critically important in
hemorrhagic shock (HS) combat casualties in remote areas where blood is not available …

The complement system has been implicated in early inflammatory events and a variety of
shock states. In rats, we measured complement activation after hemorrhage and examined …

Background: Traumatic coagulopathy contributes to early death by exsanguination and late
death in multiple organ failure. Recombinant Factor VIIa (rFVIIa, NovoSeven) is a …

Introduction Coagulopathy after sever injury predicts the requirements of blood products,
organ failure and mortality in traumatic patients. The early onset and complexity of traumatic …

Trauma-induced coagulopathy (TIC) is a global inflammatory state accompanied by
coagulation derangements, acidemia, and hypothermia, which occurs after traumatic injury …

BACKGROUND Hemorrhagic shock contributes to coagulopathy after trauma. We
investigated daily changes of coagulation components and coagulation function for 5 days …

Background: Coagulopathic bleeding is a leading cause of in-hospital death after injury. A
recently proposed transfusion strategy calls for early and aggressive frozen plasma …