Carbon monoxide protects against hemorrhagic shock and resuscitation–induced microcirculatory injury and tissue injury
I Nassour, B Kautza, M Rubin, D Escobar, J Luciano… - Shock, 2015 - journals.lww.com
Traumatic injury is a significant cause of morbidity and mortality worldwide. Microcirculatory
activation and injury from hemorrhage contribute to organ injury. Many adaptive responses …
activation and injury from hemorrhage contribute to organ injury. Many adaptive responses …
Effects of blood components and whole blood in a model of severe trauma-induced coagulopathy
GR Stettler, EE Moore, GR Nunns, M Kelher… - Journal of Surgical …, 2021 - Elsevier
Background Plasma resuscitation ameliorates hyperfibrinolysis (HF) and trauma-induced
coagulopathy (TIC). However, the use of other blood components to reduce HF has not been …
coagulopathy (TIC). However, the use of other blood components to reduce HF has not been …
Acute traumatic coagulopathy: from endogenous acute coagulopathy to systemic acquired coagulopathy and back
MJ Cohen, M West - Journal of Trauma and Acute Care Surgery, 2011 - journals.lww.com
Trauma remains the leading cause of death and disability in adults and is responsible for
more life lost and, more importantly, quality life lost than heart disease, human …
more life lost and, more importantly, quality life lost than heart disease, human …
Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model
NV Malkevich, F Dong, CA VanderMolen… - Journal of Trauma …, 2008 - journals.lww.com
Background: Rapid resuscitation with oxygen-carrying fluids is critically important in
hemorrhagic shock (HS) combat casualties in remote areas where blood is not available …
hemorrhagic shock (HS) combat casualties in remote areas where blood is not available …
Detrimental effects of complement activation in hemorrhagic shock
JG Younger, N Sasaki, MD Waite… - Journal of applied …, 2001 - journals.physiology.org
The complement system has been implicated in early inflammatory events and a variety of
shock states. In rats, we measured complement activation after hemorrhage and examined …
shock states. In rats, we measured complement activation after hemorrhage and examined …
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage
Background: Traumatic coagulopathy contributes to early death by exsanguination and late
death in multiple organ failure. Recombinant Factor VIIa (rFVIIa, NovoSeven) is a …
death in multiple organ failure. Recombinant Factor VIIa (rFVIIa, NovoSeven) is a …
A time course study of acute traumatic coagulopathy prior to resuscitation: from hypercoagulation to hypocoagulation caused by hypoperfusion?
K Duan, W Yu, Z Lin, S Tan, X Bai, L Xu, Y Dong… - … and Apheresis Science, 2014 - Elsevier
Introduction Coagulopathy after sever injury predicts the requirements of blood products,
organ failure and mortality in traumatic patients. The early onset and complexity of traumatic …
organ failure and mortality in traumatic patients. The early onset and complexity of traumatic …
Trauma-induced coagulopathy: What you need to know
L Buzzard, M Schreiber - Journal of Trauma and Acute Care …, 2024 - journals.lww.com
Trauma-induced coagulopathy (TIC) is a global inflammatory state accompanied by
coagulation derangements, acidemia, and hypothermia, which occurs after traumatic injury …
coagulation derangements, acidemia, and hypothermia, which occurs after traumatic injury …
Different recovery profiles of coagulation factors, thrombin generation, and coagulation function after hemorrhagic shock in pigs
WZ Martini, DS Cortez, MA Dubick… - Journal of Trauma and …, 2012 - journals.lww.com
BACKGROUND Hemorrhagic shock contributes to coagulopathy after trauma. We
investigated daily changes of coagulation components and coagulation function for 5 days …
investigated daily changes of coagulation components and coagulation function for 5 days …
Clotting factor deficiency in early trauma-associated coagulopathy
Background: Coagulopathic bleeding is a leading cause of in-hospital death after injury. A
recently proposed transfusion strategy calls for early and aggressive frozen plasma …
recently proposed transfusion strategy calls for early and aggressive frozen plasma …