β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during
diabetes. Islet remodeling supports this compensation, but its drivers remain poorly …

Aims/hypothesis Mild islet inflammation has been suggested as a contributing factor to beta
cell failure in type 2 diabetes. Macrophage levels are elevated in the islets of humans and …

Chronic systemic inflammation is a hallmark feature of obesity and type 2 diabetes. Both
resident and recruited islet macrophages contribute to the proinflammatory milieu of the …

The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …

Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to
type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

OBJECTIVE—Chronic pancreatitis, characterized by pancreatic exocrine tissue destruction
with initial maintenance of islets, eventually leads to insulin-dependent diabetes in most …

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …

Pancreatic islets are clusters of endocrine cells that secrete different hormones to regulate
blood glucose levels. Efficient hormone secretion requires a close interaction of endocrine …

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …